DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and mkrn1

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_004912513.1	Gene:	mkrn1 / 100485650	XenbaseID:	XB-GENE-959144	Length:	451	Species:	Xenopus tropicalis

Alignment Length:	315	Identity:	96/315 - (30%)
Similarity:	132/315 - (41%)	Gaps:	87/315 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PVPSTNSPSSQIEQKGNE--------------------AIVPNY-------KAATAGEQ------ 48
            |..|...|||.|..|..|                    ..||..       .|.|.|.|
Frog   106 PSESPAEPSSNINSKAAELAASELAAGGPQAEDWVNAVEFVPGQLYSGRAPDAYTQGTQKEDECR 170

  Fly    49 ------------------GEAQAGATCTTV-----------AVRPSGVATSADIVKGSSSVSSHV 84
                              ||.:.|..|..:           .:.|...|..:..:|  |.:.:|
Frog   171 EQPADPELKKQLCPYAAVGECRYGENCVYLHGDPCDMCGLQVLHPVDTAQRSQHIK--SCIEAH- 232

  Fly    85 QPSWRSSFA--RSQDKKCGICFETIMEKEG-GDKRFGILPSCNHVFCFQCICTWRHATQYAYQVT 146
            :.....|||  ||:|..||||.|.:.||.. |::|||||.:|:|.:|.:||..||.|.|:..::.
Frog   233 EKDMELSFAVQRSKDIVCGICMEVVYEKTNPGERRFGILSNCSHSYCLKCIRKWRSAKQFESKII 297

  Fly   147 RACPECRVWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFKQGQGVCLFGNKCFYKHSIP 211
            ::|||||:.||||.||.:|||||..|.:||..:..||..:.|:||.:|:|.|.||..|||||:.|
Frog   298 KSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKSCRYFDEGRGTCPFGGNCFYKHAYP 362

  Fly   212 NADYVDVGLPTHALGLPIPSDFSGLGNCLILVPFPNMFF--------DDFSNSDD 258
            :....:          |.|...||:.: .......|.|:        |.|.|.:|
Frog   363 DGRIEE----------PQPRQKSGMSS-RYRSQRRNRFWDFDERDGADPFENDED 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	25/54 (46%)
mkrn1	XP_004912513.1	YTH1	<35..>92	CDD:227416
		zf-CCCH_4	68..87	CDD:375512
		PHA03096	<190..339	CDD:222981	57/151 (38%)
		RING-HC_MKRN1_3	247..307	CDD:319644	28/59 (47%)
		RING-HC finger (C3HC4-type)	250..303	CDD:319644	24/52 (46%)
		MKRN1_C	369..436	CDD:374139	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020