DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic4 and SLC25A27

DIOPT Version :9

Sequence 1:	NP_001262021.1	Gene:	Dic4 / 40039	FlyBaseID:	FBgn0036808	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_004268.3	Gene:	SLC25A27 / 9481	HGNCID:	21065	Length:	323	Species:	Homo sapiens

Alignment Length:	331	Identity:	85/331 - (25%)
Similarity:	148/331 - (44%)	Gaps:	66/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DEPEGLLP---RW------WFGGFASMCVAFAVAPIDIVKTHMQIQRQK---------------- 53
            :|.|.|||   ||      ...|.|:.....|..|:|:.||.:|:|.:.
Human     5 EEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYR 69

  Fly    54 ---RSILGTVKRIHSLKGYLGFYDGFSAAILRQMTSTNIHFIVYDTGKKMEYVD-RDSYLGK--- 111
               |:.||.::.    :|:|..:.|.:.||.|.        :||..|:.:.|.. |:...||
Human    70 GMVRTALGIIEE----EGFLKLWQGVTPAIYRH--------VVYSGGRMVTYEHLREVVFGKSED 122

  Fly   112 --------IILGCVAGACGSAFGIPTDLINVRMQTDMKE----PPYKRRNYKHVFDGLIRIPKEE 164
                    :|.|.:||..|.....||||:.|:||.:.|.    .|.:.|...|.|   .:|..|.
Human   123 EHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAF---AKILAEG 184

  Fly   165 GWKALYKGGSVAVFKSSLSTCSQIAFYDIIKTEVRKNISVNDGLPLHFLTSLGTSIISSAITHPL 229
            |.:.|:.|....:.:::|.....:..||.:|..:..|..:.|.:..|.|:||.:.:::|.:..|.
Human   185 GIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPA 249

  Fly   230 DVVRTIMMNS-RPGEFR-TVFQASVHMMRFGVMGP-----YRGFVPTIVRKAPATTLLFVLYEQL 287
            ||:::.:||. |..:.| .::::|...:...|.|.     |:||:|:.:|..|.:.:.::.||::
Human   250 DVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI 314

  Fly   288 RLHFGI 293
            |...|:
Human   315 REMSGV 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic4	NP_001262021.1	PTZ00169	26..288	CDD:240302	76/303 (25%)
		Mito_carr	26..100	CDD:278578	21/92 (23%)
		Mito_carr	104..201	CDD:278578	29/112 (26%)
		Mito_carr	211..292	CDD:278578	24/87 (28%)
SLC25A27	NP_004268.3	Mito_carr	20..118	CDD:365909	23/109 (21%)
		Solcar 1	21..115		23/105 (22%)
		Mito_carr	125..219	CDD:365909	26/96 (27%)
		Solcar 2	125..217		26/94 (28%)
		Solcar 3	226..317		25/90 (28%)
		Mito_carr	227..317	CDD:365909	24/89 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810