Protein Alignment Dic4 and UCP2

DIOPT Version :10

• Sequence 1: NP_649054.1
• Gene: Dic4 / 40039
• FlyBaseID: FBgn0036808
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 82/284 - (28%)
• Similarity: 145/284 - (51%)
• Gaps: 24/284 - (8%)

  Fly    24 WFGGFASMCVAFAVA-PIDIVKTHMQIQ------------RQKRSILGTVKRIHSLKGYLGFYDG 75
            :.|...:.|:|..:. |:|..|..:|||            .|.|.::||:..:...:|....|:|
Human    17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNG 81

  Fly    76 FSAAILRQMTSTNIHFIVYDTGKKMEYV---DRDSYLGKIILGCVAGACGSAFGIPTDLINVRMQ 137
            ..|.:.|||:..::...:||:.|:. |.   :..|...:::.|...||...|...|||::.||.|
Human    82 LVAGLQRQMSFASVRIGLYDSVKQF-YTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQ 145

  Fly   138 TDMKEPPYKRRNYKHVFDGLIRIPKEEGWKALYKGGSVAVFKSSLSTCSQIAFYDIIKTEVRKNI 202
            ...:....:|  |:...:....|.:|||::.|:||.|..|.::::..|:::..||:||..:.|..
Human   146 AQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKAN 208

  Fly   203 SVNDGLPLHFLTSLGTSIISSAITHPLDVVRTIMMNSRPGEFRTVFQASVHMMRFGVMGP---YR 264
            .:.|.||.||.::.|....::.|..|:|||:|..|||..|::.:....::.|::  ..||   |:
Human   209 LMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQ--KEGPRAFYK 271

  Fly   265 GFVPTIVRKAPATTLLFVLYEQLR 288
            ||:|:.:|......::||.||||:
Human   272 GFMPSFLRLGSWNVVMFVTYEQLK 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic4	NP_649054.1	Mito_carr	26..100	CDD:395101	23/86 (27%)
		Mito_carr	104..201	CDD:395101	27/96 (28%)
		Mito_carr	211..292	CDD:395101	27/81 (33%)
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	24/94 (26%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		23/88 (26%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		11/45 (24%)
		transmembrane domain	17..34		3/16 (19%)
		transmembrane domain	78..100		6/21 (29%)
		Mito_carr	112..206	CDD:395101	27/95 (28%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		27/90 (30%)
		transmembrane domain	120..137		4/16 (25%)
		transmembrane domain	174..197		6/22 (27%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		30/86 (35%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	27/81 (33%)
		purine nucleotide binding domain	264..273		3/8 (38%)
		transmembrane domain	269..291		7/21 (33%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)