Protein Alignment Dic4 and SLC25A35

DIOPT Version :10

• Sequence 1: NP_649054.1
• Gene: Dic4 / 40039
• FlyBaseID: FBgn0036808
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001307799.1
• Gene: SLC25A35 / 399512
• HGNCID: 31921
• Length: 300
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 65/290 - (22%)
• Similarity: 109/290 - (37%)
• Gaps: 32/290 - (11%)

  Fly    27 GFASMCVAFAVAPIDIVKTHMQI----------QRQKRSILGTVKRIHSLKGYLGFYDGFSAAIL 81
            |.|:........|:::|||.||:          ||..|::......|..:.|......|.:.|:|
Human     7 GLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGLAPALL 71

  Fly    82 RQMTSTNIHFIVYDTGKKMEYV----DRDSYLGKIILGCVAGACGSAFGIPTDLINVRMQTDMKE 142
            .|.....|....|...:...|:    ...|.......|.:||..|:..|.|..::...:|.....
Human    72 YQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAAS 136

  Fly   143 PPYKRRNYKH--VFDGLIRIPKEEGWKALYKG--GSV--AVFKSSLSTCSQIAFYDIIKTEVRKN 201
            .......|||  :|..|..|.::.|...|::|  |.:  .:..||...|:..:..|::.   :..
Human   137 EIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLS---QWE 198

  Fly   202 ISVNDGLPLHFLTSLGTSIISSAITHPLDVVRTIMMNSRPGE-------FRTVFQASVHMMRF-G 258
            |.......|..:.::.:.|.......|.||..|.:.| :|.:       :|.:..|.:...|. |
Human   199 IFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYN-QPTDAQGKGLMYRGILDALLQTARTEG 262

  Fly   259 VMGPYRGFVPTIVRKAPATTLLFVLYEQLR 288
            :.|.|:|...:..|..|.|.|....::|||
Human   263 IFGMYKGIGASYFRLGPHTILSLFFWDQLR 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic4	NP_649054.1	Mito_carr	26..100	CDD:395101	19/82 (23%)
		Mito_carr	104..201	CDD:395101	22/102 (22%)
		Mito_carr	211..292	CDD:395101	21/86 (24%)
SLC25A35	NP_001307799.1	Solcar 1	1..90		19/82 (23%)
		Mito_carr	2..84	CDD:395101	18/76 (24%)
		Solcar 2	100..193		21/92 (23%)
		PTZ00169	<122..294	CDD:240302	39/175 (22%)
		Solcar 3	203..294		22/91 (24%)
		Mito_carr	209..298	CDD:395101	21/85 (25%)