DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic4 and SLC25A10

DIOPT Version :9

Sequence 1:	NP_001262021.1	Gene:	Dic4 / 40039	FlyBaseID:	FBgn0036808	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001257882.1	Gene:	SLC25A10 / 1468	HGNCID:	10980	Length:	406	Species:	Homo sapiens

Alignment Length:	178	Identity:	69/178 - (38%)
Similarity:	103/178 - (57%)	Gaps:	8/178 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EGLLPRWWFGGFASMCVAFAVAPIDIVKTHMQIQRQ-KRSILGTVKRIHSLKGYLGFYDGFSAAI 80
            |..:.||:|||.||...|....|:|::|.|:|.|:: |..:.|...|:....|.|..|.|.||::
Human     4 EARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILALYSGLSASL 68

  Fly    81 LRQMTSTNIHFIVYDTGKKMEYVDRDS-----YLGKIILGCVAGACGSAFGIPTDLINVRMQTDM 140
            .||||.:...|.:|:|.:  :.|.:.|     :..|::||.|:|..|...|.|.||:|||||.|:
Human    69 CRQMTYSLTRFAIYETVR--DRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDV 131

  Fly   141 KEPPYKRRNYKHVFDGLIRIPKEEGWKALYKGGSVAVFKSSLSTCSQI 188
            |.|..:||||.|..|||.|:.:|||.:.|:.|.::|..:.:|.|..|:
Human   132 KLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQL 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic4	NP_001262021.1	PTZ00169	26..288	CDD:240302	65/169 (38%)
		Mito_carr	26..100	CDD:278578	27/74 (36%)
		Mito_carr	104..201	CDD:278578	37/90 (41%)
		Mito_carr	211..292	CDD:278578
SLC25A10	NP_001257882.1	Mito_carr	13..93	CDD:278578	28/81 (35%)
SLC25A10	NP_001257882.1	Mito_carr	95..179	CDD:278578	35/83 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S759
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45618
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.750