DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp27a1.2

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_001334004.3	Gene:	cyp27a1.2 / 795106	ZFINID:	ZDB-GENE-081104-511	Length:	522	Species:	Danio rerio

Alignment Length:	528	Identity:	149/528 - (28%)
Similarity:	258/528 - (48%)	Gaps:	52/528 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLRANSQLAATRNPDASSYVQ------QLESEWEGAKPFTELPGPTRWQ-LFRGFQKGGEYHQLG 66
            |.|:.:..||.    ||..||      :.|::....|.||.|     :| ||:|:.  ...|:|
Zfish    26 GFRSAAGNAAA----ASVSVQDGHRKLKTEADLPEIKIFTML-----YQMLFKGYL--NSVHEL- 78

  Fly    67 MDDVMRLYKKQ-FGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKD 130
                 :||:|| :|.:..|..  |....:...:||..|::.|.:.::|.||.......:|:.|..
Zfish    79 -----QLYQKQVYGPLWKINA--GNLQGISISSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGI 136

  Fly   131 EFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRD-KESQEVP 193
            .:     |.| ..|.:|.|.|:.:|..::..::...|...:..|...|:.||..:|: ..:.::.
Zfish   137 SY-----GPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLV 196

  Fly   194 GDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFDLGVRPSLYR-YIP 257
            .:..|.:...:.|.:|::..:..:|.| |...|.|..|....|..:......:.:.|:..| |.
Zfish   197 SNLTNELYRFSLEGIASILFETRIGCL-EKEIPAETQKFINFIAQMFTYSMHVALLPNWTRKYF- 259

  Fly   258 TPTYKKFSRAMDEIFDTCSMYVNQAIERIDRK--SSQGDSNDHKSVLEQLLQIDRKLAVVMAMDM 320
             |.::|:....|.||...:..::..:|.|.::  ::|..:.::.:.|....:|.||.......::
Zfish   260 -PFWQKYIDGWDGIFKFGTKMIDMKMEAIQKRVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSEL 323

  Fly   321 LMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRL 385
            |:.|||:||..:...|..|:|:||.|:.|.:|| :|:.......|.|::.|:|:|:|||||:|||
Zfish   324 LLAGVDSTSNTMLWALYLLSKDPEAQETLYQEV-TKVLKDDRIPTAEEVNSMPFLKAVIKETLRL 387

  Fly   386 YPVTFGNAR-SAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDV 449
            |||...|:| .|..:||:..|..||.|...:.:..:.:|::::|..::|.||||||   |.::..
Zfish   388 YPVVPVNSRLIAETEVVIGEYFFPKKTTFTLCHYVISRDEKVFPEPQKFKPERWLR---DGRTRP 449

  Fly   450 LMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYST-EKPYKCRFLYKPNI 513
                  |.|..:|||||.|.|||:||.:|||.|.:|.|::.|.:..:.:. |.....|.:..||.
Zfish   450 ------NPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRSVLVPNK 508

  Fly   514 PLKFKFTD 521
            .:...|.:
Zfish   509 KVNLHFVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	132/465 (28%)
cyp27a1.2	XP_001334004.3	p450	66..505	CDD:278495	132/466 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.780