DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp27b1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001298720.1	Gene:	cyp27b1 / 793309	ZFINID:	ZDB-GENE-111005-2	Length:	505	Species:	Danio rerio

Alignment Length:	495	Identity:	134/495 - (27%)
Similarity:	232/495 - (46%)	Gaps:	41/495 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KPFTELPGPTRWQLFRG-FQKGG--EYHQLGMDDVMR---LYKKQFGDICLIPGLFGMPSTVFTF 97
            |...::|||:..:..|. |.|.|  ..|||.::...:   ::|..||.|.          ||...
Zfish    39 KTLEQMPGPSPARFIRDLFMKRGFSRLHQLQLEGRQKYGPMWKASFGPIL----------TVHVA 93

  Fly    98 NVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHR 161
            ..|..::|.|.|||.|||........||..|.:.:     ||. ..|.||...||.::..:::.:
Zfish    94 EPELIQQVLRQEGQHPVRSELSSWKDYRALRGEGY-----GLLTAEGEEWQCVRSLLSKHMLRPQ 153

  Fly   162 NVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPP 226
            .|..|...:..|....:.:::....:.|..:..|..........|.:::|..:..:|.| :|..|
Zfish   154 AVEAYDGALNAVVSDLLQKLKLRSQESSSRIVSDISAEFYRFGLEGISSVLFESRIGCL-DAVVP 217

  Fly   227 PEASKLFKNIEVL-MDSFFDLGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKS 290
            .|..:..::|..: :.:...:.:...|:|.:|.| :..|.|..|.:|:....:::|.::...:|.
Zfish   218 VETERFIQSINTMFVMTLLTMAMPQWLHRLLPKP-WDTFCRCWDVMFEFAKGHIDQRLQEEKQKL 281

  Fly   291 SQGDSNDHKSVLEQLLQIDRKLAVVMA--MDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEV 353
            ..|:..:.:.:...|.|....|..|.:  .::|:.||||.|:.:|..|..|:::|:.|..||:||
Zfish   282 ECGEQLEGRYLTYFLSQAGLPLTSVYSNVTELLLAGVDTISSTLSWSLYELSRHPDVQTALRDEV 346

  Fly   354 LSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNS 418
            ||.:.. .|.....|:.::|.|:||:||.||||||...|||....|:.:.||.|||.|.:.:.:.
Zfish   347 LSVMKD-RSVPQASDVAAMPLLKAVVKEILRLYPVIPANARVINKDIEVGGYVIPKNTLITLCHY 410

  Fly   419 FLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELT 483
            ...:|.:.:.....|.|:||     .|:||     ..:.:..:|||.|.|.|:|:||.:||:.|.
Zfish   411 ATSRDPQQFRDPDSFRPQRW-----GDRSD-----RSHPYATVPFGVGKRSCIGRRIAELEVYLA 465

  Fly   484 VANLVRNFHIE--YNYSTEKPYKCRFLYKPNIPLKFKFTD 521
            ::.::.:|.:|  ....|..| ..|.|..|...:..:||:
Zfish   466 LSRILMHFTMEPVRENDTVHP-MTRTLLVPERQIDLRFTE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	127/468 (27%)
cyp27b1	NP_001298720.1	p450	45..493	CDD:278495	130/476 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.980