DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	513	Identity:	128/513 - (24%)
Similarity:	221/513 - (43%)	Gaps:	58/513 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKPFTELP--GPTRWQLFRGFQKGGEYHQL--GMDDVMR----LYKKQFGDICLIPGLFGMPSTV 94
            |:.|.|:|  |...|.....|.:.|.:.::  .|::..|    :|::..|         ...|..
Zfish   219 ARLFQEIPDTGSNGWMNLLRFWRDGRFSRMHKHMEESFRRLGPIYREHLG---------SQSSVN 274

  Fly    95 FTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLM 158
            ....::|.| ::|:||..|.|...:|...:|..|     ::..|:| .||.||..:|..:|..:|
Zfish   275 IMLPMDTGE-LFRSEGLHPRRMTLQPWATHRETR-----RHSKGVFLKNGTEWRADRLLLNREVM 333

  Fly   159 QHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTIN------HLTFESVATVALDREL 217
            ...:|..:|..:..|.:.|...:|.....:..|..|....|::      ....|:...|.....:
Zfish   334 VSSSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKAGQHTLTLDPSPDLFRFALEASCHVLYGERI 398

  Fly   218 GLLREANPPPEASKLFKNIEVLMDSFFDLGVRPSLYRYIP--------TPTYKKFSRAMDEIFDT 274
            ||.... |..|:.:....:|.:      |...|.|. |:|        ...:...:.|.|:||..
Zfish   399 GLFSSC-PSDESERFISAVERM------LATTPPLL-YLPPRLLLRLRASLWTTHATAWDDIFSH 455

  Fly   275 CSMYVNQAIERIDRKSSQGDSNDHKSVLEQLL---QIDRKLAVVMAMDMLMGGVDTTSTAISGIL 336
            ....:.::.:|:..:.|.........||.:|:   |:..:|......:::.||||||:..:...|
Zfish   456 AEQRIQRSYQRLQARPSAAPDCSFPGVLGKLMEAGQLSLELIRANITELMAGGVDTTAVPLQFAL 520

  Fly   337 LNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVV 401
            ..||:||:.|:.:|.:|||.......: .::.::..|.|:..|||:||||||.....|....|:|
Zfish   521 FELARNPDVQECVRAQVLSSWQQASGD-PLKALQGAPLLKGTIKETLRLYPVGITVQRYPVRDIV 584

  Fly   402 LDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFG 466
            |..|.:|.||.:.:....|.:...::.|.:.|.|.||....|...:        ..|..|.||||
Zfish   585 LQNYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRWSADADAGSA--------GGFRSLAFGFG 641

  Fly   467 PRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPNIPLKFKFTDLKY 524
            .|.|||:||.:.||:|.:.:::|.|.:..:.:.|...|...:.:|..|.:..|:.|.:
Zfish   642 SRQCVGRRIAENEMQLLLMHILRTFKLTVSSTEELSTKYTLILQPECPPRITFSTLTH 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	120/482 (25%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820