Protein Alignment Cyp12c1 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 106/507 - (20%)
• Similarity: 207/507 - (40%)
• Gaps: 102/507 - (20%)

  Fly    25 SSYVQQLESEWEGAKPFTELPGPTRWQLFRGFQKGGEYHQLGMDDVMRLYK-------------K 76
            |.|:..:..:::      .:|||.|...|.|       |...|   :||.|             :
 Frog    26 SGYIHYIHMKYD------HIPGPPRDSFFLG-------HSPTM---LRLMKNNLLMYDHFLGWVQ 74

  Fly    77 QFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLFG 141
            ::|.:..|.||..:  .:...:.|..:::..:.                ...||:|:.....:||
 Frog    75 KYGPVVRINGLHRV--IILVVSPEAVKELLMSP----------------KYSKDKFYDVIANMFG 121

  Fly   142 ------------NGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPG 194
                        :...|.|.|..::|...:     .||..:.   ..|..:..|:.:|..::..|
 Frog   122 VRFMGKGLVTDRDYDHWHKQRRIMDPAFSR-----TYLMGLM---GPFNEKAEELMEKLMEKADG 178

  Fly   195 ----DFMNTINHLTFESVATVALDRELGLLR-EANPPPEASKLFKNIEVLMDSFFDLGVRPSLYR 254
                ...:.::.||.:.:..||...||..|. :..|.|:|      |.::|....::  |..:.|
 Frog   179 KCEIKMHDMLSRLTLDVIGKVAFGMELNSLNDDLTPFPKA------ISLVMKGIVEM--RNPMVR 235

  Fly   255 YIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLL-------QIDRKL 312
            |  :...:.|.|.:.|..........:.|||..::...|:... ..:|.|:|       :.|.::
 Frog   236 Y--SLAKRGFIRKVQESIRLLRQTGKECIERRQKQIQDGEEIP-VDILTQILKGAAMEEECDPEI 297

  Fly   313 AVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRA 377
            .:...:...:.|.:||:..:|.:::.|.:|||..::.:.|: .::.....:...||:..|.||..
 Frog   298 LLDNFVTFFIAGQETTANQLSFVVMELGRNPEILEKAQAEI-DEVIGSKRDIEYEDLGKLQYLSQ 361

  Fly   378 VIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRK 442
            |:||:|||||...|.:|....|:|:||.::|:...:::.:..:.:.::.|.....|.|:|:  ..
 Frog   362 VLKETLRLYPTAPGTSRGLTEDMVIDGVKVPENVTIMLNSYIMGRMEQYYSDPLTFNPDRF--SP 424

  Fly   443 DDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIE 494
            |..|.         .:.|.||..|||.|:|:....:|.::.:|.|::.:..|
 Frog   425 DAPKP---------YYSYFPFSLGPRSCIGQVFSQMEAKVVMAKLLQRYEFE 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	93/443 (21%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	93/451 (21%)