Protein Alignment Cyp12c1 and cyp27a1.3

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_002934001.3
• Gene: cyp27a1.3 / 594905
• XenbaseID: XB-GENE-18386061
• Length: 518
• Species: Xenopus tropicalis
• Alignment Length: 535
• Identity: 140/535 - (26%)
• Similarity: 251/535 - (46%)
• Gaps: 55/535 - (10%)

  Fly     6 VKHGLRANSQLA---ATRNPDASSYVQQLESEWEGAKPFTELPGPT-----RWQLFRGFQKGGEY 62
            ::...|||.|..   ||.....::.|     |.:..|...:||||:     .|...||:.  ...
 Frog    14 LQQSCRANVQTVRKKATLGVSGATVV-----EGKTLKTLDDLPGPSPLKLLYWIFLRGYL--FRT 71

  Fly    63 HQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNK 127
            |:|.:     ::||.:|.:..:..  ...:.|...:.:..|.:.|.||::|.|.....:..:|:.
 Frog    72 HELQV-----IFKKTYGPMWKMSD--RQHAMVTVASPDLLESLLRKEGKYPTRADMFIMREHRDL 129

  Fly   128 RKDEFFKNCMGLFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEV 192
            |...:..    :...|.:|.:.|:.:|..:::.|...:|...|..|....:.:|:|:   .:|..
 Frog   130 RGHSYGP----VTEEGHQWHRIRTILNQRMLKPRETVVYAGSMNEVVSDLLLKIKEL---TAQSS 187

  Fly   193 PGDFMNTINHL----TFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFDLGVRPSLY 253
            .|..:|.:..|    .|||:.||..:..||.|.: ...||..|...:|.::::....|...|...
 Frog   188 SGTQVNGVAELMYKFAFESICTVLFETRLGCLNK-EILPETQKFIDSIGIMLEHLTMLTRLPQWT 251

  Fly   254 RYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGD--SNDHKSVLEQLLQIDRKLAVVM 316
            :.| .|.:.::..|.|.|||.....:::.:|.|:.:..:|:  ..::.:.|....::..:.....
 Frog   252 KGI-LPYWGRYIEAWDTIFDFGKKLIDKKMEDIEGRLKRGEEVEGEYLTYLLSSGKLSMEEVYGS 315

  Fly   317 AMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKS---LPYLRAV 378
            .:::|..||||||..::..|..|::|||.|..|.:||:..:..    .|:.|.::   :|.|:||
 Frog   316 VVELLQAGVDTTSNTLTWALYQLSRNPEIQNNLYQEVIRVIPG----ETIPDSEAIARMPLLKAV 376

  Fly   379 IKESLRLYPVTFGNARSAG-ADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRK 442
            |||:|||:||...|||... .:|.:..|..|..|:.::.:..:.:|:..:|.|..|:||||||
 Frog   377 IKETLRLFPVVPENARMINEKEVTIKDYVFPVKTQFILGHYAISRDETTFPEADRFLPERWLR-- 439

  Fly   443 DDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYST-EKPYKCR 506
                 |..|..  :.|..:|||:|.|.|||:||.:|||.|.::.:::.|.:..:... |...|.|
 Frog   440 -----DSGMKH--HPFGSIPFGYGVRACVGRRIAELEMHLALSRIIKMFQVIPDPDLGEVGAKNR 497

  Fly   507 FLYKPNIPLKFKFTD 521
            .:...|.|:..:|.:
 Frog   498 AVLVANRPVNLRFIE 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	120/450 (27%)
cyp27a1.3	XP_002934001.3	cytochrome_P450	79..508	CDD:477761	121/452 (27%)