Protein Alignment Cyp12c1 and cyp11a1.2

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_691817.1
• Gene: cyp11a1.2 / 563363
• ZFINID: ZDB-GENE-130911-1
• Length: 512
• Species: Danio rerio
• Alignment Length: 539
• Identity: 140/539 - (25%)
• Similarity: 243/539 - (45%)
• Gaps: 81/539 - (15%)

  Fly     5 TVKHGLRANSQLAATRNPDASSYVQQLESEWEGAKPFTELPGPTRWQL--FRGFQKGGEYHQLGM 67
            ::||.|    |:..||:..|.:...|..:    .:||.|:||..|..|  ...|.|.|     |:
Zfish    16 SLKHLL----QVIVTRSGRAPAIGLQDST----VRPFNEIPGQWRNSLKSVFAFAKMG-----GL 67

  Fly    68 DDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKV-----------YRTEGQWPVRGGAEPV 121
            .::.|:....|       ..||   .::...|..:|.|           ::.||.:|.|...:..
Zfish    68 RNIHRIMVHNF-------NTFG---PIYREKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAW 122

  Fly   122 IHYRNKRKDEFFKNCMG-LFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIR 185
            ..||:.|..::     | |..:|.:|..||..:|..::..:....::..:..|.:.||.|:.:..
Zfish   123 TAYRDYRNRKY-----GVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNKKI 182

  Fly   186 DKESQEVPGDFMNTINHLTF----ESVATVALDRELGLLREANPPPE------ASKLFKNIEVLM 240
            ::..|   ..:...::|..|    |||:.|.....||||.:...|..      .:.:||....:
Zfish   183 ERSGQ---NQWTTDLSHELFKFALESVSAVLYGERLGLLLDYIDPDSQRFIDCITLMFKTTSPM- 243

  Fly   241 DSFFDLGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQL 305
                 |.:.|.|.|.|.:..::....|.|.||:.....: |.|.|..||:.:|:.. :..||..|
Zfish   244 -----LYLPPGLLRPIRSKIWRNHVEAWDGIFNQADRCI-QNIYRQLRKNPEGNGK-YTGVLASL 301

  Fly   306 LQIDRKLAV----VMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTV 366
            |.:| ||::    ....:::.||||||:..:...|..||:||:.|:.:|.|:.:...:...:. |
Zfish   302 LMLD-KLSIEDIKASVTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAEISAARIASKGDM-V 364

  Fly   367 EDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAK 431
            :.:|.:|.::..:||:|||:||.....|....|:|:..|.||.||.:.:....:.:|.:::|..:
Zfish   365 QMLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQLGLYAMGRDHQVFPNPE 429

  Fly   432 EFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYN 496
            :::|.||            :|...:.|..|.||||||.|:|:||.:.||:|.:.:::.||.||..
Zfish   430 QYLPSRW------------VNSQNHYFKSLSFGFGPRQCLGRRIAETEMQLFLIHMLENFRIEKQ 482

  Fly   497 YSTEKPYKCRFLYKPNIPL 515
            ...|.......:..|..|:
Zfish   483 RQMEVKSMFELILLPEKPI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	120/466 (26%)
cyp11a1.2	XP_691817.1	cytochrome_P450	78..501	CDD:477761	119/462 (26%)