Protein Alignment Cyp12c1 and Cyp11b1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_036669.3
• Gene: Cyp11b1 / 500892
• RGDID: 2453
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 502
• Identity: 135/502 - (26%)
• Similarity: 233/502 - (46%)
• Gaps: 77/502 - (15%)

  Fly    39 KPFTELPGPTR--W----QLFRGFQKGGEYHQLGMDDVMR----LYKKQFGDICLIPGLFGMPST 93
            |||..:|..:|  |    |:.|  ::|.|...|.|....:    :::...|...::..:  :|
  Rat    36 KPFEAIPQYSRNKWLKMIQILR--EQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVM--LP-- 94

  Fly    94 VFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL-----FGNGAEWGKNRSAV 153
                  |..||:::.|...|.|...||.:.:|..|         ||     ..|||:|..||..:
  Rat    95 ------EDAEKLHQVESILPHRMPLEPWVAHRELR---------GLRRGVFLLNGADWRFNRLQL 144

  Fly   154 NPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDF-----MNTINHLTFESVATVAL 213
            ||.::..:.:..::..:..|.|.||..:::   :..:.|.|..     .|..|: |.|:...|..
  Rat   145 NPNMLSPKAIQSFVPFVDVVARDFVENLKK---RMLENVHGSMSINIQSNMFNY-TMEASHFVIS 205

  Fly   214 DRELGLLREANPPPEAS------KLFKNIEVLMDSFFDLGVRPSLYRYIPTPTYKKFSRAMDEIF 272
            ...|||......|...:      .:||:...||      .:..||.|:..|..:|:..    :.:
  Rat   206 GERLGLTGHDLKPESVTFTHALHSMFKSTTQLM------FLPKSLTRWTSTRVWKEHF----DSW 260

  Fly   273 DTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLLQIDRKLAVVMA--MDMLMGGVDTTSTAISGI 335
            |..|.||.:.|:.:.|:.::|.......:.|.:.|....:..:.|  |:::.|.||||:.::...
  Rat   261 DIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMT 325

  Fly   336 LLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADV 400
            |..||:||:.||.||:|.|:...|:.:. ..:.|..||.|||.:||:||||||.....|...:|:
  Rat   326 LFELARNPDVQQALRQESLAAEASIVAN-PQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDL 389

  Fly   401 VLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGF 465
            ||..|.:|.||.:::....:.::..::||.:.::|:|||.||             .:|.:|.|||
  Rat   390 VLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERK-------------RSFQHLAFGF 441

  Fly   466 GPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPN 512
            |.|.|:|:|:.::||.|.:.::::.|.:|.....:.....|||..|:
  Rat   442 GMRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	123/455 (27%)
Cyp11b1	NP_036669.3	cytochrome_P450	72..495	CDD:477761	123/464 (27%)