DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp27b1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001006907.1	Gene:	cyp27b1 / 448754	XenbaseID:	XB-GENE-942527	Length:	506	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	142/538 - (26%)
Similarity:	247/538 - (45%)	Gaps:	57/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVKHGLRANSQL-AATRNPDASSYVQQLESEWEGAKPFTELPGPTR----WQLF--RGFQKGGEY 62
            |:|.|...:||| ...:...|.:.::..|...:|.|...::|||:.    ..||  ||..:   .
Frog     4 TLKLGSSRSSQLFRGLQELWAETVLKNSEKVIKGHKSLADMPGPSTVSFISDLFCRRGLAR---L 65

  Fly    63 HQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNK 127
            |:|.::.     |.:||.:.  ...||...||........|:|.|.||:.|:|...       :.
Frog    66 HELQLEG-----KAKFGPVW--KASFGPILTVHVAEPSLIEQVLRQEGKHPIRSDL-------SS 116

  Fly   128 RKDEFFKNCMG-----LFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDK 187
            .||  ::.|.|     |...|.||.:.||.:...:::.:.|..|...:..|....:.:|...|.:
Frog   117 WKD--YRQCRGHSYGLLTAEGEEWQQFRSILGKHMLKPKEVEAYSDVLNDVVGDLIKKINYQRSQ 179

  Fly   188 ESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVL-MDSFFDLGVRPS 251
            ....|..|..........|.:::|..:..:|.| |...|.|..|..::|..: :.:...:.:...
Frog   180 NQNNVVKDIAKEFYMFGLEGISSVLFESRIGCL-EPTVPKETEKFIQSINTMFVMTLLTMAMPKF 243

  Fly   252 LYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLLQ--IDRKLAV 314
            |::....| ::||..:.|.:|.....::::.::.:.:|.:||:..:.|.:...|.|  |..|...
Frog   244 LHKIFRKP-WQKFCESWDYMFAFAKGHIDKRMKDVAQKLAQGEKVEGKYLTYYLAQEKIPMKSIY 307

  Fly   315 VMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVI 379
            ....::|:.||||.|:.:|..|..||::|:.|..:..||...|...... :..|:..:|.|:||:
Frog   308 GNVTELLLAGVDTISSTLSWSLYELAQHPDIQSAVYSEVEEILQGKQIP-SPSDVARMPLLKAVV 371

  Fly   380 KESLRLYPVTFGNAR-SAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKD 443
            ||.||||||..|||| .|..|:.:..|.|||.|.:.:.:....:|:.::....||.|:|||:::|
Frog   372 KEVLRLYPVIPGNARVVADRDIQVGDYIIPKKTLITLCHYATSRDENVFSNPNEFQPDRWLKKED 436

  Fly   444 DDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYK---- 504
            ..          :.:..||||||.|.|:|:||.:||:.|.:|.::.:|.::    .|:|..
Frog   437 TH----------HPYASLPFGFGKRSCIGRRIAELEVYLALARILSHFEVK----PEQPGSLVMP 487

  Fly   505 -CRFLYKPNIPLKFKFTD 521
             .|.|..|...:..:|.:
Frog   488 MTRTLLVPEKEINLQFLE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	127/471 (27%)
cyp27b1	NP_001006907.1	p450	45..503	CDD:365848	131/493 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3591
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9361
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.010