Protein Alignment Cyp12c1 and Cyp12a4

DIOPT Version :9

• Sequence 1: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 241/501 - (48%)
• Similarity: 333/501 - (66%)
• Gaps: 14/501 - (2%)

  Fly    32 ESEWEGAKPFTELPGPTRWQL-FRGFQKGGEYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVF 95
            :|||..||||.::|....|.| .:....||:|..:.:.::....::.:|||..:||:.|.|..:.
  Fly    38 DSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLS 102

  Fly    96 TFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQ 159
            |.|.:.||.|:|.||.||.|.|...::::|.:.:.:|::..||:. ..|..||..|:.|||||||
  Fly   103 THNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQ 167

  Fly   160 HRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREAN 224
            .:||.:|.|.|.:||::||.||.|:||.::.|.|.||::|||..|.|||:.||||::||||:.:|
  Fly   168 PKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSN 232

  Fly   225 PPPEASKLFKNIEVLMDSFF----DLGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIER 285
            ...||.|||.    .:|.||    ||.::||.:|||.||..|:..||:|.|.:....||::||||
  Fly   233 KESEALKLFH----YLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIER 293

  Fly   286 IDRKSSQG--DSNDHKSVLEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQR 348
            :|:::.:|  ...:.:||||:||::|||:|.||||||||.||||||:..:.:||.||||||||.|
  Fly   294 LDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQAR 358

  Fly   349 LREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKL 413
            |||||:..|.:.:||||...||::|||||.||||.||:|:..||||....|.||.|||:|.||.:
  Fly   359 LREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYV 423

  Fly   414 LMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMN--KDLNAFIYLPFGFGPRMCVGKRIV 476
            .:.....|..|..:|:|.||:||||||...|.:|....|  |..|.|::||||||||||||||||
  Fly   424 NIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIV 488

  Fly   477 DLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPNIPLKFKFTDL 522
            ::|:||..|.|:|||::|:||.||..::...:..|||||||||.||
  Fly   489 EMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDL 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	223/466 (48%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	224/462 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445003
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	12	11.750