Protein Alignment Cyp12c1 and Cyp49a1

DIOPT Version :9

• Sequence 1: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 166/520 - (31%)
• Similarity: 277/520 - (53%)
• Gaps: 20/520 - (3%)

  Fly    14 SQLAATRNPDASSYVQQLESEWEGAKPFTELPGPTRWQL----FRGFQKGGEYHQLGMDDVMRLY 74
            :.:|.||...:|...:...|.....:|::|:|||....|    :|.....|.|....:|.||...
  Fly    73 TSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNEL 137

  Fly    75 KKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL 139
            ...:|.:..:.||.|.|..:|.|:.:....:::.|...|.|.....:.||:...:.:||.:..||
  Fly   138 HVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGL 202

  Fly   140 FG-NGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHL 203
            .| :|.:|...|..|..:|:|.:....|:.|:..:..:|:.||..:|| |..|:|.:|::.:...
  Fly   203 IGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD-EKDELPANFLHELYKW 266

  Fly   204 TFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFF----DLGVRPSLYRYIPTPTYKKF 264
            ..|||..|:||..||.|     .||.|:..:.|...:::||    :|.:|..|:|..||..|:.|
  Fly   267 ALESVGRVSLDTRLGCL-----SPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSF 326

  Fly   265 SRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHK--SVLEQLLQI--DRKLAVVMAMDMLMGGV 325
            .:|:|:....|...:.:.:::.|...::|.|....  |::|::::.  :||||.::|:|:.:.||
  Fly   327 VKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGV 391

  Fly   326 DTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTF 390
            ||||.|.|..:..|||||:||::|.:|:........::.....::.:|||||.:||:||:.||..
  Fly   392 DTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVI 456

  Fly   391 GNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDL 455
            .|.||..:|.|::||.:||||.::..:..:..|...:|..|.|:|||||::..|.......|:.:
  Fly   457 ANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKI 521

  Fly   456 NAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPNIPLKFKFT 520
            :.|:.||||||.|||||:|..::|:...:|.:.|.:.:.|| |.|..|:....|.|..||.||.|
  Fly   522 HPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN-SGEFVYRVNSTYIPQSPLNFKLT 585

  Fly   521  520
              Fly   586  585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	151/469 (32%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	150/467 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
	11	10.900