DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and Cyp11b3

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_861545.1	Gene:	Cyp11b3 / 353498	RGDID:	727886	Length:	498	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	133/496 - (26%)
Similarity:	233/496 - (46%)	Gaps:	65/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KPFTELPGPTR--W----QLFRGFQKGG---EYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTV 94
            |||..:|..:|  |    |:.|...:..   |.|| ...::..:::...|...::..:  :|
  Rat    35 KPFEAIPQYSRNKWLKMIQILREQSQENLHLEMHQ-AFQELGPIFRHSAGGAQIVSVM--LP--- 93

  Fly    95 FTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL-----FGNGAEWGKNRSAVN 154
                 |..||:::.|...|.|...|..:.:|..|         ||     ..|||:|..||..:|
  Rat    94 -----EDAEKLHQVESILPRRMTLESWVAHRELR---------GLRRGVFLLNGADWRFNRLQLN 144

  Fly   155 PVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPG----DFMNTINHLTFESVATVALDR 215
            |.::..:.|..::..:..|.|.||..:::   :..:.|.|    |..:.:.:.|.|:...|....
  Rat   145 PNMLSPKAVQSFVPFVDVVARDFVENLKK---RMLENVHGSMSMDIQSNVFNYTMEASHFVISGE 206

  Fly   216 ELGLL-REANPPPEASKLFKNIEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMY 278
            .|||. .:.|  ||:.|....:..:..|...|...| :|.|:..|..:|    ...|.:|..|.|
  Rat   207 RLGLTGHDLN--PESLKFIHALHSMFKSTTQLMFLPKNLTRWTSTQVWK----GHFESWDIISEY 265

  Fly   279 VNQAIERIDRKSSQGDSNDHKSVLEQLLQIDRKLAVVMA--MDMLMGGVDTTSTAISGILLNLAK 341
            |.:.|:.:.|:.::|.......:.|.:.|....:..:.|  |:::.|.||||:.::...|..||:
  Rat   266 VTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELAR 330

  Fly   342 NPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYR 406
            ||:.||.||:|.|:...|:.:. ..:.|..||.|||.:||:|||||:.....|...:|:||..|.
  Rat   331 NPDVQQALRQESLAAEASIAAN-PQKAMSDLPLLRAALKETLRLYPIGSSLERIVDSDLVLQNYH 394

  Fly   407 IPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCV 471
            :|.||.:::....:.::..::||.:.::|:|||.||             .:|.:|.||||.|.|:
  Rat   395 VPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLERK-------------RSFQHLAFGFGVRQCL 446

  Fly   472 GKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPN 512
            |:|:.::|:.|.:.::::.|.:|.....:.....||:..||
  Rat   447 GRRLAEVEVLLLLHHMLKIFQVETLRQEDVQMAYRFVLMPN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	126/478 (26%)
Cyp11b3	NP_861545.1	p450	41..494	CDD:278495	130/490 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820