Protein Alignment Cyp12c1 and CYP27C1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 161/511 - (31%)
• Similarity: 246/511 - (48%)
• Gaps: 57/511 - (11%)

  Fly    36 EGAKPFTELPGP-TRWQLFRGFQKGG--EYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTF 97
            ||.:....:||| |...|...|.:.|  ..|     ::.:.:.:::|.|  ....||....|...
Human    61 EGPRSLAAMPGPRTLANLAEFFCRDGFSRIH-----EIQQKHTREYGKI--FKSHFGPQFVVSIA 118

  Fly    98 NVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHR 161
            :.:...:|.|.||..|.|...|....||:.|     ....||. ..|.:|.|.||.:...:::.:
Human   119 DRDMVAQVLRAEGAAPQRANMESWREYRDLR-----GRATGLISAEGEQWLKMRSVLRQRILKPK 178

  Fly   162 NVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTF----ESVATVALDRELGLLRE 222
            :||||...:.:|....:.||..:|   ||...|:.:..:|.|.|    |.|||:..:..||.|.
Human   179 DVAIYSGEVNQVIADLIKRIYLLR---SQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLE- 239

  Fly   223 ANPPPEASKLFKNIEVLMDSFFD----LGVRPSLYR-YIPTPTYKKFSRAMDEIFDTCSMYVNQA 282
             |..|:.:..:.....||.|.|.    .|..|...| :||.| :::|.|:.|.:|....::|:..
Human   240 -NSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP-WREFCRSWDGLFKFSQIHVDNK 302

  Fly   283 IERIDRKSSQGDSNDHKSV---------LEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLN 338
            :..|..:..:|     :.|         |.|.|.:....|.|  .:||:.||||||..:|..:..
Human   303 LRDIQYQMDRG-----RRVSGGLLTYLFLSQALTLQEIYANV--TEMLLAGVDTTSFTLSWTVYL 360

  Fly   339 LAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLD 403
            ||::||.||.:..|::..|...|.. |..|:..:|.:||::||:|||:||..||.|....|:|:.
Human   361 LARHPEVQQTVYREIVKNLGERHVP-TAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIG 424

  Fly   404 GYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPR 468
            ||.|||||:|.:.:......|..:||||||.||||||:.|.|:.|        .|..:|||.|.|
Human   425 GYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVD--------NFGSIPFGHGVR 481

  Fly   469 MCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPY-KCRFLYKPNIPLKFKFTDLK 523
            .|:|:||.:||:.|.|..|:::|.|:.:..|...: |...|..|..|:..:|.:.|
Human   482 SCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	149/459 (32%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	149/460 (32%)