DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp27a1.4

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001315442.1	Gene:	cyp27a1.4 / 322341	ZFINID:	ZDB-GENE-030131-1060	Length:	522	Species:	Danio rerio

Alignment Length:	534	Identity:	149/534 - (27%)
Similarity:	259/534 - (48%)	Gaps:	56/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVKHGLRANSQLAATRNPDASSYVQ------QLESEWEGAKPFTELPGPTRWQ-LFRGFQKGGEY 62
            |...|.|.    ||..:..||..||      :.|::....|.||.|     :| ||:|:.  ...
Zfish    22 TAATGFRR----AAGNSAAASVSVQDGHRKLKTEADLPEIKIFTML-----YQMLFKGYL--NSV 75

  Fly    63 HQLGMDDVMRLYKKQ-FGDICLI--PGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHY 124
            |:|      :||:|| :|.:..|  ..|.|:..|    :||..|::.|.:.::|.||.......:
Zfish    76 HEL------QLYQKQVYGPLWKINAGNLQGISIT----SVELLEELLRKDEKYPCRGYMTLWTEH 130

  Fly   125 RNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRD-K 187
            |:.|...:     |.| ..|.:|.|.|:.:|..::..::...|...:..|...|:.||..:|: .
Zfish   131 RDLRGISY-----GPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMS 190

  Fly   188 ESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFDLGVRPSL 252
            .:.::..:..|.:...:.|.:|::..:..:|.| |...|.|..:...:|..:......:.:.|:.
Zfish   191 PTGDLVSNLTNELYRFSLEGIASILFETRIGCL-EKEIPAETQEFINSIAQMFTYNMHVALLPNW 254

  Fly   253 YR-YIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRK--SSQGDSNDHKSVLEQLLQIDRKLAV 314
            .| |:  |.::|:....|.||...:..:|..:|.|..:  ::|..:.::.:.|....::..|...
Zfish   255 TRNYL--PFWQKYIDGWDGIFKFGTKMINLKMEAIQTRLDTNQEVAGEYLTYLLSSGKMSCKDVY 317

  Fly   315 VMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVI 379
            ....::|:.||||||..:...|..|:|:|..|:.|.:|| :|:.......|.|::.|:|:|:|||
Zfish   318 GSVSEVLLAGVDTTSNTMLWALYLLSKDPAAQETLHQEV-TKVLKGDRIPTAEEVNSMPFLKAVI 381

  Fly   380 KESLRLYPVTFGNAR-SAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKD 443
            ||:||||||...|:| .|.::|::..|..||.|...:.:..:..|::::|..::|.||||||
Zfish   382 KETLRLYPVVPVNSRLIAESEVIIGEYLFPKKTTFNLFHYAISHDEKVFPEPQKFKPERWLR--- 443

  Fly   444 DDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYST-EKPYKCRF 507
            |.::..      |.|..:|||||.|.|||:||.:|||.|.:|.|::.|.:..:.:. |.....|.
Zfish   444 DGRTRP------NPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRS 502

  Fly   508 LYKPNIPLKFKFTD 521
            :..||..:...|.:
Zfish   503 VLVPNKKVNLHFVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	131/467 (28%)
cyp27a1.4	NP_001315442.1	p450	66..505	CDD:278495	131/468 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.780