DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and cyp26a1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_571221.2	Gene:	cyp26a1 / 30381	ZFINID:	ZDB-GENE-990415-44	Length:	492	Species:	Danio rerio

Alignment Length:	504	Identity:	127/504 - (25%)
Similarity:	217/504 - (43%)	Gaps:	118/504 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GEYHQLGMD--DVMRLYKKQFGDICLI-PGLFGMPSTVFTFNVETFEKVYRTEG-----QWP--V 114
            ||..||.:.  ..:|:.::::|  |:. ..|||.| ||.....:...::...|.     |||  |
Zfish    55 GETLQLILQRRKFLRMKRQKYG--CIYKTHLFGNP-TVRVMGADNVRQILLGEHKLVSVQWPASV 116

  Fly   115 RG--GAEPV-----IHYRNKRKDEFFKNCMGLFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQR 172
            |.  |::.:     :.::||:     |..|..|...|             ::|     |:..:|
Zfish   117 RTILGSDTLSNVHGVQHKNKK-----KAIMRAFSRDA-------------LEH-----YIPVIQ- 157

  Fly   173 VNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASK-----L 232
              ::..:.|:|...|:|..:   ....:..|.|.....:.|..|          ||..|     |
Zfish   158 --QEVKSAIQEWLQKDSCVL---VYPEMKKLMFRIAMRILLGFE----------PEQIKTDEQEL 207

  Fly   233 FKNIEVLMDSFFDLGVR---PSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGD 294
            .:..|.::.:.|.|.:.   ..|||.:         ||.:        :::..||...||..|.|
Zfish   208 VEAFEEMIKNLFSLPIDVPFSGLYRGL---------RARN--------FIHSKIEENIRKKIQDD 255

  Fly   295 SND----HKSVLEQLLQIDRK------LAVV--MAMDMLMGGVDTTSTAISGILLNLAKNPEKQQ 347
            .|:    :|..|:.|::..|:      |..:  .|.::|.||.:||::..:.:::.|..|.|..|
Zfish   256 DNENEQKYKDALQLLIENSRRSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQ 320

  Fly   348 RLREEVLSKL-TSLHSE---FTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIP 408
            ::||||..|: ..:::.   .::|.:..|.|...||||:||:.|...|..|.|.....|:||:||
Zfish   321 KVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVALKTFELNGYQIP 385

  Fly   409 KGTKLL--MTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCV 471
            ||..::  :.::..:.|  ::|...||.|||::.:..:|.|         .|.|:|||.|.||||
Zfish   386 KGWNVIYSICDTHDVAD--VFPNKDEFQPERFMSKGLEDGS---------RFNYIPFGGGSRMCV 439

  Fly   472 GKRIVDLEMELTVANLVRNFHIEYNYSTEKP-YKCRFLYKP--NIPLKF 517
            ||....:.:::.:..|.:  |..:..|...| .|......|  |:|.||
Zfish   440 GKEFAKVLLKIFLVELTQ--HCNWILSNGPPTMKTGPTVYPVDNLPTKF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	120/484 (25%)
cyp26a1	NP_571221.2	p450	14..487	CDD:299894	127/504 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D871849at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010