DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12c1 and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_849178.2	Gene:	Cyp27a1 / 301517	RGDID:	727915	Length:	533	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	138/521 - (26%)
Similarity:	249/521 - (47%)	Gaps:	74/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HGL-----RANSQLAA-------TRNPDASSYVQQLESEWEGAKPFTELPGP-TRWQLFRGFQKG 59
            |||     ||.:.:.|       |..|.......:|.|       ..||||| |...||:.|.:|
  Rat    21 HGLCPQGARAKAAIPAALRDHESTEGPGTGQDRPRLRS-------LAELPGPGTLRFLFQLFLRG 78

  Fly    60 GEYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHY 124
               :.|.:.::..|.|.::|.:...  .||..:.|...:....|:|.|.||::|:|...|....:
  Rat    79 ---YVLHLHELQALNKAKYGPMWTT--TFGTRTNVNLASAPLLEQVMRQEGKYPIRDSMEQWKEH 138

  Fly   125 RNKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKE 188
            |:.:...:     |:| ..|.:|...|.::|..:::....|:|...:..|...|:.|:.::|.:.
  Rat   139 RDHKGLSY-----GIFITQGQQWYHLRHSLNQRMLKPAEAALYTDALNEVISDFIARLDQVRTES 198

  Fly   189 S--QEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEAS------KLFKNIEVLMDSFFD 245
            :  .:|| |..:.:.||..|::..:..::.:|.|..:.|...|:      .:|||...:  :|..
  Rat   199 ASGDQVP-DVAHLLYHLALEAICYILFEKRVGCLEPSIPEDTATFIRSVGLMFKNSVYV--TFLP 260

  Fly   246 LGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSND-------HKSVLE 303
            ...||.|      |.:|::....|.||......::|.::.|:.:......:.       |..:.:
  Rat   261 KWSRPLL------PFWKRYMNNWDNIFSFGEKMIHQKVQEIEAQLQAAGPDGVQVSGYLHFLLTK 319

  Fly   304 QLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEV-----LSKLTSLHSE 363
            :||.....:...  .::::.||||||..::..|.:|:||||.|:.|.:||     ..|:..
  Rat   320 ELLSPQETVGTF--PELILAGVDTTSNTLTWALYHLSKNPEIQEALHKEVTGVVPFGKVPQ---- 378

  Fly   364 FTVEDMKSLPYLRAVIKESLRLYPVTFGNAR-SAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLY 427
              .:|...:|.|:|||||:||||||...|:| ....:..::|:..||.|:.::.:..:.:|..::
  Rat   379 --NKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVF 441

  Fly   428 PRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFH 492
            |..:.|.|.||||:::||.|.:     .:.|..:|||:|.|.|:|:||.:|||:|.::.|::.:.
  Rat   442 PEPESFQPHRWLRKREDDNSGI-----QHPFGSVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYE 501

  Fly   493 I 493
            :
  Rat   502 V 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	126/472 (27%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58		3/19 (16%)
		cytochrome_P450	91..527	CDD:425388	116/441 (26%)
		Sterol-binding. /evidence=ECO:0000255	386..400		10/13 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780