Protein Alignment Cyp12c1 and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_963966.1
• Gene: Cyp24a1 / 25279
• RGDID: 2462
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 464
• Identity: 140/464 - (30%)
• Similarity: 227/464 - (48%)
• Gaps: 46/464 - (9%)

  Fly    42 TELPGPTRWQLFRG----FQKGGEYHQLGMDDVMRLYKKQFGDICLIP-GLF-----GMPSTVFT 96
            |.|||||.|.|...    |.|||...|   .|.:..|.|::|.|..:. |.|     |.||.:
  Rat    56 TSLPGPTNWPLLGSLLEIFWKGGLKKQ---HDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL-- 115

  Fly    97 FNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL-FGNGAEWGKNRSAVNPVLMQH 160
                  |.:||||...|.|...:|...||:.|.:.:     || ...|.||.:.|||....||:.
  Rat   116 ------EALYRTESAHPQRLEIKPWKAYRDHRNEAY-----GLMILEGQEWQRVRSAFQKKLMKP 169

  Fly   161 RNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANP 225
            ..:....|.:..|...|:.|:.|:.| |...:| |..:.:|..:|||:..|..::..|||:: ..
  Rat   170 VEIMKLDKKINEVLADFLERMDELCD-ERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQK-ET 231

  Fly   226 PPEASKLFKNIEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRK 289
            ..||......|:.:|.:|..:.|.| .|::.:.|..::..:.|.|.||.:....::..::|.
  Rat   232 EEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRY--- 293

  Fly   290 SSQGDSNDHKSVLEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVL 354
             ||....|....:.|...:.:|.......::.:..|:||:.::..||.||::||:.|:||.:||.
  Rat   294 -SQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQ 357

  Fly   355 SKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSF 419
            |.|....:. ..||::::|||:|.:|||:||.|......|:.....||..|.:||||.|.:....
  Rat   358 SVLPDNQTP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQV 421

  Fly   420 LLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTV 484
            |...:..:..:.:|.|||||:::          |.:|.|.:||||.|.|||:|:|:.:|::.|.:
  Rat   422 LGSSEDNFEDSHKFRPERWLQKE----------KKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476

  Fly   485 ANLVRNFHI 493
            ..:::.:.|
  Rat   477 CWIIQKYDI 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	125/426 (29%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	125/427 (29%)