Protein Alignment Cyp12c1 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 105/506 - (20%)
• Similarity: 199/506 - (39%)
• Gaps: 121/506 - (23%)

  Fly    79 GDICLIPGLFGMPSTVFTFN---------------VETFEKVYRTEGQWPV-------------R 115
            |.:..:|.  |:.|..:.|:               :|..|..|...|  ||             .
Human    55 GHLVQLPA--GVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYG--PVFSFTMVGKTFTYLL 115

  Fly   116 GGAEPVIHYRNKR-----KDEFFKNCMGLFGNGAEWGKNRSAVNPVLMQHR-------NVAIYLK 168
            |.....:.:.:|.     :|.:.:....:||.|..:    ...|||.::.:       |:|.:
Human   116 GSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAY----DVPNPVFLEQKKMLKSGLNIAHF-- 174

  Fly   169 PMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLF 233
                  :|.|:    |.:||::|....:..:.....||:::.:.:......|.......:.::..
Human   175 ------KQHVS----IIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKV 229

  Fly   234 KNIEVLMDSFFD--LGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSN 296
            ..:...:|..|.  ..:.|.   ::|.|::::..||..||.|.  .|  :||::  |:.||...:
Human   230 AQLYADLDGGFSHAAWLLPG---WLPLPSFRRRDRAHREIKDI--FY--KAIQK--RRQSQEKID 285

  Fly   297 DHKSVLEQLLQ---------IDRKLAVVMAMDMLMGGVDTTST--AISGILLNLAKNPEKQQRLR 350
            |   :|:.||.         .|.::| .|.:.:|:.|..|:||  |..|..|...|..:|:..|.
Human   286 D---ILQTLLDATYKDGRPLTDDEVA-GMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE 346

  Fly   351 EEVL--SKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKL 413
            ::.:  ..|..|    |.:.:|.|..|...|||:|||.|......|.|.....:.||.||.|.::
Human   347 QKTVCGENLPPL----TYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQV 407

  Fly   414 LMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNA--FIYLPFGFGPRMCVGKRIV 476
            .::           |...:.:.:.|:.|.|.:....|.:...:.  |.|:|||.|...|:|:...
Human   408 CVS-----------PTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 461

  Fly   477 DLEMELTVANLVRNFHIE--------YNYSTEKPYKCRFLYKPNIP-LKFK 518
            .::::...:.::|.:..:        .||:|       .::.|..| :::|
Human   462 YVQIKTIWSTMLRLYEFDLIDGYFPTVNYTT-------MIHTPENPVIRYK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	104/502 (21%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	97/463 (21%)