DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp12c1 and CYP27B1

DIOPT Version :9

Sequence 1:NP_001287109.1 Gene:Cyp12c1 / 40037 FlyBaseID:FBgn0036806 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_000776.1 Gene:CYP27B1 / 1594 HGNCID:2606 Length:508 Species:Homo sapiens


Alignment Length:517 Identity:142/517 - (27%)
Similarity:234/517 - (45%) Gaps:67/517 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 EWEGA-KPFTELPGP-TRWQLFRGFQKGGEYHQLGMDDVMRLYKKQ------FGDICLIPGLFGM 90
            |:..| :...::||| |...|...|.|||         :.||::.|      ||.:.|  ..||.
Human    29 EYHSARRSLADIPGPSTPSFLAELFCKGG---------LSRLHELQVQGAAHFGPVWL--ASFGT 82

  Fly    91 PSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLFGNGAEWGKNRSAVNP 155
            ..||:.......|::.|.||..|.|....|...:|..|:    :.|..|...|.||.:.||.:.|
Human    83 VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQ----RACGLLTAEGEEWQRLRSLLAP 143

  Fly   156 VLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKES------QEVPGDFMNTINHLTFESVATVALD 214
            :|::.:..|.|...:..|....|.|:|..|.:.:      ::|.|:|..    ...|.:|.|.|.
Human   144 LLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYK----FGLEGIAAVLLG 204

  Fly   215 RELGLLREANPPPEASKLFKNI-EVLMDSFFDLGVRPSLYRYIPTPTYKKFSRAMDEIFDTCSMY 278
            ..||.| ||..||:.....:.: .|.:.:...:.:...|...:|.| :.:..|..|::|    .:
Human   205 SRLGCL-EAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGP-WGRLCRDWDQMF----AF 263

  Fly   279 VNQAIERIDRKSSQGDSNDHKSVLEQ-------LLQIDRKLAVVM--AMDMLMGGVDTTSTAISG 334
            ..:.:||.:.:::..:....:..||.       |.:.:.....::  ..::|:.||||.|..:|.
Human   264 AQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSW 328

  Fly   335 ILLNLAKNPEKQQRLREEV---LSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSA 396
            .|..|:::||.|..|..|:   ||..:|.:...||  :..||.|:||:||.||||||..||:|..
Human   329 ALYELSRHPEVQTALHSEITAALSPGSSAYPSATV--LSQLPLLKAVVKEVLRLYPVVPGNSRVP 391

  Fly   397 GADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYL 461
            ..|:.:..|.|||.|.:.:.:....:|...:|....|.|.|||..          ....:.|..|
Human   392 DKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGE----------GPTPHPFASL 446

  Fly   462 PFGFGPRMCVGKRIVDLEMELTVANLVRNFHI--EYNYSTEKPYKCRFLYKPNIPLKFKFTD 521
            |||||.|.|:|:|:.:||:::.:|.::.:|.:  |...:..:| |.|.:..|...:..:|.|
Human   447 PFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRP-KTRTVLVPERSINLQFLD 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp12c1NP_001287109.1 p450 45..502 CDD:278495 134/484 (28%)
CYP27B1NP_000776.1 p450 41..505 CDD:278495 138/501 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3171
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3768
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48087
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2442
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.910

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