Protein Alignment Cyp12c1 and CYP11B1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 144/503 - (28%)
• Similarity: 234/503 - (46%)
• Gaps: 70/503 - (13%)

  Fly    40 PFTELP--GPTRW----QLFRGFQKGGE---------YHQLGMDDVMRLYKKQFGDICLIPGLFG 89
            ||..:|  ...||    |::|  ::|.|         :.:||  .:.|......|.:|::
Human    37 PFEAMPRRPGNRWLRLLQIWR--EQGYEDLHLEVHQTFQELG--PIFRYDLGGAGMVCVM----- 92

  Fly    90 MPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLFGNGAEWGKNRSAVN 154
            :|        |..||:.:.:...|.|...||.:.||..|..:    |.....||.||..||..:|
Human    93 LP--------EDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHK----CGVFLLNGPEWRFNRLRLN 145

  Fly   155 PVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPG----DFMNTINHLTFESVATVALDR 215
            |.::....|..:|..:..|.|.|...:::   |..|...|    |...:|.|.|.|:........
Human   146 PEVLSPNAVQRFLPMVDAVARDFSQALKK---KVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207

  Fly   216 ELGLLREANPPPEASKLFKN-IEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMY 278
            .|||:  .:.|..||..|.: :||:..|...|...| ||.|:.....:|:...|.|.||    .|
Human   208 RLGLV--GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF----QY 266

  Fly   279 VNQAIERIDRKSSQGDSNDHKSVLEQLL---QIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLA 340
            .:..|::|.::.:......:.|::.:||   ::........:|::..|.||||...:...|..||
Human   267 GDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELA 331

  Fly   341 KNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGY 405
            :||..||.||:|.|:...|: ||...:....||.|||.:||:||||||.....|.|.:|:||..|
Human   332 RNPNVQQALRQESLAAAASI-SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395

  Fly   406 RIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMC 470
            .||.||.:.:....|.::..|:||.:.:.|:|||..:...::          |.::|||||.|.|
Human   396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN----------FYHVPFGFGMRQC 450

  Fly   471 VGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKC--RFLYKPNI-PL 515
            :|:|:.:.||.|.:.::::  |::....|::..|.  .|:.:|:: ||
Human   451 LGRRLAEAEMLLLLHHVLK--HLQVETLTQEDIKMVYSFILRPSMFPL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	132/452 (29%)
CYP11B1	NP_000488.3	CYP11B	72..499	CDD:410737	135/466 (29%)