Protein Alignment Cyp12c1 and CYP11A1

DIOPT Version :9

• Sequence 1: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 143/536 - (26%)
• Similarity: 242/536 - (45%)
• Gaps: 72/536 - (13%)

  Fly     3 RLTVKHGLRANSQLAATRNPDASSYVQQLESEWEGAKPFTELPGP--TRW-QLFRGFQKGGEYHQ 64
            ||.|..|..|.   .:||:|                :||.|:|.|  ..| .|:..:::.|. |:
Human    29 RLRVPTGEGAG---ISTRSP----------------RPFNEIPSPGDNGWLNLYHFWRETGT-HK 73

  Fly    65 LGMDDVMR------LYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIH 123
            :.:..|..      :|:::.|::          .:|:..:.|....::::||..|.|....|.:.
Human    74 VHLHHVQNFQKYGPIYREKLGNV----------ESVYVIDPEDVALLFKSEGPNPERFLIPPWVA 128

  Fly   124 YRNKRKDEFFKNCMG-LFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRI-REIRD 186
            |.     ::::..:| |....|.|.|:|.|:|..:|.......:|..:..|:|.||:.: |.|:.
Human   129 YH-----QYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKK 188

  Fly   187 KESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFD----LG 247
            ..|....||..:.:....|||:..|......|:|.|. ..|||.:.   |:.:...|..    |.
Human   189 AGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV-VNPEAQRF---IDAIYQMFHTSVPMLN 249

  Fly   248 VRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLLQIDRKL 312
            :.|.|:|...|.|:|....|.|.||....:|.......:.:|.|.  .:|::.:|.:||. |.|:
Human   250 LPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSV--HHDYRGILYRLLG-DSKM 311

  Fly   313 AV----VMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLP 373
            :.    ....:||.|||||||..:...|..:|:|.:.|..||.|||:.......:.... ::.:|
Human   312 SFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQLVP 375

  Fly   374 YLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERW 438
            .|:|.|||:|||:|::....|....|:||..|.||..|.:.:....|.::...:...:.|.|.||
Human   376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440

  Fly   439 LRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPY 503
            |.:          :|::..|..|.||:|.|.|:|:||.:|||.:.:.|::.||.:|..:.::...
Human   441 LSK----------DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 495

  Fly   504 KCRFLYKPNIPLKFKF 519
            ....:..|..|:.|.|
Human   496 TFNLILMPEKPISFTF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	128/475 (27%)
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	131/492 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850