Protein Alignment Cyp12c1 and Cyp27b1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_034139.2
• Gene: Cyp27b1 / 13115
• MGIID: 1098274
• Length: 507
• Species: Mus musculus
• Alignment Length: 546
• Identity: 146/546 - (26%)
• Similarity: 232/546 - (42%)
• Gaps: 80/546 - (14%)

  Fly     6 VKHGLRANSQLAATRNPDASSYVQQLESEWEGAKPFTELPGPTRWQ-LFRGFQKGG--EYHQLGM 67
            |.|.:....||.|:.....|..|         .:..:::|||:... |...|.|||  ..|:|.:
Mouse    11 VFHRIHLPLQLDASLGSRGSESV---------LRSLSDIPGPSTLSFLAELFCKGGLSRLHELQV 66

  Fly    68 DDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEF 132
            ....|     :|.|.  .|.||...||:..:....|::.|.|...|.|........:|.:.:
Mouse    67 HGAAR-----YGPIW--SGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQ--- 121

  Fly   133 FKNCMGLFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKES------QE 191
             :.|..|..:|.||.:.||.:.|:|::.:..|.|...:..|.|..|.|:|..|.:.|      .:
Mouse   122 -RACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLD 185

  Fly   192 VPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNI-EVLMDSFFDLGVRPSLYRY 255
            |.|:|..    ...||:..|.|...||.| ||..||:.......: .|.:.:...:.:...|:..
Mouse   186 VAGEFYK----FGLESIGAVLLGSRLGCL-EAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHL 245

  Fly   256 IPTPTYKKFSRAMDEIFDTCSMYV----NQAIERIDRKSSQGDSNDHKSVLEQLL---QIDRKLA 313
            ||.| :.:..|..|::|.....:|    .:|..|...|..:...:.|.  |...|   ::..:..
Mouse   246 IPGP-WARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHH--LTHFLFREKVSVQSI 307

  Fly   314 VVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTV-----------E 367
            |....::|:.||||.|..:|..|..|:::|:.|           |:||||.|.           .
Mouse   308 VGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQ-----------TALHSEITAGTRGSCAHPHGT 361

  Fly   368 DMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKE 432
            .:..||.|:|||||.||||||..||:|....|:.:..|.||:.|.:.:.:....:|...:|....
Mouse   362 ALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNS 426

  Fly   433 FIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHI--EY 495
            |.|.|||..          ....:.|..||||||.|.|:|:|:.:||:::.::.::.:|.:  |.
Mouse   427 FNPARWLGE----------GPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEP 481

  Fly   496 NYSTEKPYKCRFLYKPNIPLKFKFTD 521
            .....|| ..|.:..|...:..:|.|
Mouse   482 GALPIKP-MTRTVLVPERSINLQFVD 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	126/466 (27%)
Cyp27b1	NP_034139.2	CYP27B1	68..502	CDD:410741	127/474 (27%)