DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and Cyp11b2

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_034121.4	Gene:	Cyp11b2 / 13072	MGIID:	88584	Length:	500	Species:	Mus musculus

Alignment Length:	497	Identity:	138/497 - (27%)
Similarity:	232/497 - (46%)	Gaps:	66/497 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KPFTELPGPTR--W----QLFRGFQKGGEYHQLGMDDVMR----LYKKQFGDICLIPGLFGMPST 93
            :||..:|..:|  |    |:.|  ::|.|...|.|..|.|    :::...|...::..:  :|
Mouse    36 QPFEAIPQYSRNKWLKMIQILR--EQGQENLHLEMHQVFRELGPIFRHSVGKTQIVSVM--LP-- 94

  Fly    94 VFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL-----FGNGAEWGKNRSAV 153
                  |..||:::.|...|.|...||.:.:|..|         ||     ..||.||..||..:
Mouse    95 ------EDAEKLHQVESMLPRRMHLEPWVAHRELR---------GLRRGVFLLNGPEWRLNRLRL 144

  Fly   154 NPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPG----DFMNTINHLTFESVATVALD 214
            |..::..:.|..::..:..|.|.|:..::|   |..|...|    |...::.:.|.|:.......
Mouse   145 NRNVLSPKAVQKFVPMVDMVARDFLETLKE---KVLQNARGSLTMDVQQSLFNYTIEASNFALFG 206

  Fly   215 RELGLLREANPPPEASKLFKNIEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMY 278
            ..||||.. :..|.:.|....:..:..|...|...| ||.|:..|..:|:...|.|.|    |.|
Mouse   207 ERLGLLGH-DLSPGSLKFIHALHSMFKSTSQLLFLPKSLTRWTSTRVWKEHFDAWDVI----SEY 266

  Fly   279 VNQAIERIDRKSSQGDSNDHKSVLEQLL-QIDRKLAVVMA--MDMLMGGVDTTSTAISGILLNLA 340
            .|:.|.::.::...|.|..:..::.:|: |....|..:.|  |::..|.||||:..:...|..||
Mouse   267 ANRCIWKVHQELRLGSSQTYSGIVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVMTLFELA 331

  Fly   341 KNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGY 405
            :||:.|:.||:|.|:...|:.:. ..:.|..||.|||.:||:||||||.....|...:|:||..|
Mouse   332 RNPDVQKALRQESLAAEASIAAN-PQKAMSDLPLLRAALKETLRLYPVGGFLERILSSDLVLQNY 395

  Fly   406 RIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMC 470
            .:|.||.:|:....:.::..::||.:.::|:|||.||             .:|.:|.||||.|.|
Mouse   396 HVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERK-------------RSFQHLAFGFGVRQC 447

  Fly   471 VGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPN 512
            :|:|:.::||.|.:.::::.|.:|.....:.....||:..|:
Mouse   448 LGRRLAEVEMMLLLHHILKTFQVETLRQEDVQMAYRFVLMPS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	133/479 (28%)
Cyp11b2	NP_034121.4	p450	42..496	CDD:365848	136/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920