DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12c1 and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus

Alignment Length:	523	Identity:	138/523 - (26%)
Similarity:	238/523 - (45%)	Gaps:	61/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LESEWEG---------------AKPFTELPGP--TRW-QLFRGFQKGG----EYHQL-GMDDVMR 72
            |...|:|               .:.|.|:|.|  ..| .|:..:::.|    .|||: .......
Mouse    20 LSPTWQGPVLSTGKGAGTSTSSPRSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGP 84

  Fly    73 LYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCM 137
            :|:::.|.:          .:|:..:.:....::..||..|.|....|.:.|.     ::::..:
Mouse    85 IYREKLGTL----------ESVYIVDPKDASILFSCEGPNPERFLVPPWVAYH-----QYYQRPI 134

  Fly   138 G-LFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRI-REIRDKESQEVPGDFMNTI 200
            | ||.:...|.|:|..:|..:|....:..::..::.|.:.|:..: |.|:.:.|....|...:.:
Mouse   135 GVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDL 199

  Fly   201 NHLTFESVATVALDRELGLLREANPPPEASKLFKNI-EVLMDSFFDLGVRPSLYRYIPTPTYKKF 264
            ...:|||:::|.....:|:|.|. ..|||.:....: ::...|...|.:.|..:|.:.|.|:|..
Mouse   200 FRFSFESISSVIFGERMGMLEEI-VDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDH 263

  Fly   265 SRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLL---QIDRKLAVVMAMDMLMGGVD 326
            :.|.|.||:....|.......:.:|.   |.:.:..||..||   ::..|.......:||.||||
Mouse   264 AAAWDVIFNKADEYTQNFYWDLRQKR---DFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVD 325

  Fly   327 TTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFG 391
            |||..:...|..:|.|.:.|:.||.|||:.......:. .:.::.:|.|:|.|||:|||:|::..
Mouse   326 TTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDM-AKMVQLVPLLKASIKETLRLHPISVT 389

  Fly   392 NARSAGADVVLDGYRIPKGTKLLMTNSFLL-KDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDL 455
            ..|....|:||..|:||..| |:...||.: :|...:|...:|.|.|||.:          :::.
Mouse   390 LQRYTVNDLVLRNYKIPAKT-LVQVASFAMGRDPGFFPNPNKFDPTRWLEK----------SQNT 443

  Fly   456 NAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPNIPLKFKFT 520
            ..|.||.||:|.|.|:|:||.:|||.:.:.||:.||.||.....:...|...:..|..|:.|.|.
Mouse   444 THFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQ 508

  Fly   521 DLK 523
            .||
Mouse   509 PLK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	126/471 (27%)
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		2/18 (11%)
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	130/488 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900