DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12c1 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_001287109.1	Gene:	Cyp12c1 / 40037	FlyBaseID:	FBgn0036806	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_446215.1	Gene:	Cyp27b1 / 114700	RGDID:	69192	Length:	501	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	146/538 - (27%)
Similarity:	233/538 - (43%)	Gaps:	70/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VKHGLRANSQLAATRNPDASSYVQQLESEWEGAKPFTELPGP-TRWQLFRGFQKGG--EYHQLGM 67
            |.|.::..|||.      :.|.::.|          :::||| |...|...|.|||  ..|:|.:
  Rat    11 VFHRVQLPSQLG------SDSVLRSL----------SDIPGPSTPSFLAELFCKGGLSRLHELQV 59

  Fly    68 DDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEF 132
            ....|     :|.|.  .|.||...||:..:....|::.|.|...|.|........:|.:.:
  Rat    60 HGAAR-----YGPIW--SGSFGTLRTVYVADPALVEQLLRQESHCPERCSFSSWSEHRRRHQ--- 114

  Fly   133 FKNCMGLFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIRDKES------QE 191
             :.|..|..:|.||.:.||.:.|:|::.:..|.|...:..|....|.|:|..|.:.|      .:
  Rat   115 -RACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDSVVSDLVRRLRRQRGRGSGLPDLVLD 178

  Fly   192 VPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNI-EVLMDSFFDLGVRPSLYRY 255
            |.|:|..    ...|.:..|.|...||.| ||..||:.....:.: .|.:.:...:.:...|:|.
  Rat   179 VAGEFYK----FGLEGIGAVLLGSRLGCL-EAEVPPDTETFIEAVGSVFVSTLLTMAMPSWLHRL 238

  Fly   256 IPTPTYKKFSRAMDEIFDTCSMYVNQ----AIERIDRKSSQGDSNDHKSVLEQLL---QIDRKLA 313
            ||.| :.:..|..|::|.....:|.|    |..|...|..:.....|.  |...|   ::..:..
  Rat   239 IPGP-WARLCRDWDQMFAFAQKHVEQREGEAAVRNQGKPEEDLPTGHH--LTHFLFREKVSVQSI 300

  Fly   314 VVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKL---TSLHSEFTVEDMKSLPYL 375
            |....::|:.||||.|..:|..|..|:::||.|..|..|:...:   :..|.:.|.  :..||.|
  Rat   301 VGNVTELLLAGVDTVSNTLSWALYELSRHPEVQSALHSEITGAVNPGSYAHLQATA--LSQLPLL 363

  Fly   376 RAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLR 440
            :|||||.||||||..||:|....|:.:..|.||:.|.:.:.:....:|...:.....|.|.|||.
  Rat   364 KAVIKEVLRLYPVVPGNSRVPDRDICVGNYVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWLG 428

  Fly   441 RKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHI--EYNYSTEKPY 503
            .          ....:.|..||||||.|.|:|:|:.:||:::.:|.::.:|.:  |......||
  Rat   429 E----------GPAPHPFASLPFGFGKRSCIGRRLAELELQMALAQILTHFEVLPEPGALPVKP- 482

  Fly   504 KCRFLYKPNIPLKFKFTD 521
            ..|.:..|...:..:|.|
  Rat   483 MTRTVLVPERSIHLQFVD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	133/478 (28%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	126/466 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880