Protein Alignment Cyp12c1 and Cyp11b1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001028401.3
• Gene: Cyp11b1 / 110115
• MGIID: 88583
• Length: 499
• Species: Mus musculus
• Alignment Length: 495
• Identity: 146/495 - (29%)
• Similarity: 238/495 - (48%)
• Gaps: 63/495 - (12%)

  Fly    39 KPFTELPGPTR--W----QLFRGFQKGGEYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTF 97
            :||..:|..:|  |    |:.|  ::|.|...|.|..|.|    :.|.|  .....|....||..
Mouse    36 QPFEAIPQYSRNKWLKMIQILR--EQGQENLHLEMHQVFR----ELGPI--FRHSVGKTQIVFVT 92

  Fly    98 NVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGL-----FGNGAEWGKNRSAVNPVL 157
            ..|..||:|:.|...|.|...|..|.:|..|         ||     ..||.||..||..:||.:
Mouse    93 LPEDVEKLYQVESTHPCRMPLESWIVHRELR---------GLGRGVFLLNGPEWYFNRLQLNPNV 148

  Fly   158 MQHRNVAIYLKPMQRVNRQFVNRIREIRDKESQEVPG----DFMNTINHLTFESVATVALDRELG 218
            :..:.|..::..:..:.|.||:.:::   |..:.|.|    ||.:::.:.|.|:...|.....||
Mouse   149 LSPKAVQKFVPLVDGIARDFVDNLKK---KMLESVHGSFSMDFQSSVFNYTIEASHFVLFGERLG 210

  Fly   219 LL-REANPPPEASKLFKNIEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQ 281
            |: |:.:  |::.|....:..:..:...|...| ||.|:..|..:|:..    |.:|..|.||.:
Mouse   211 LIGRDLS--PDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENL----ESWDFISEYVTK 269

  Fly   282 AIERIDRKSSQGD----SNDHKSVLEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKN 342
            .|:.:.|:.::|.    |...:.|.|:.|.:|...|  .:|:::.|..|||||.:......||:|
Mouse   270 CIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQA--NSMELIAGSTDTTSTPLVMTFFELARN 332

  Fly   343 PEKQQRLREEVLSKLTSLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRI 407
            |:.||.||:|.|:...|:.:. ..:.|..||.|||.:||:||||||.....|...:|:||..|.:
Mouse   333 PDVQQALRQESLAAEASIAAN-PQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLVLQNYHV 396

  Fly   408 PKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVG 472
            |.||.|.:....:.::..::||.:.::|:|||.||             .:|.:|.||||.|.|:|
Mouse   397 PAGTVLNVNLYSMGRNPAVFPRPERYMPQRWLERK-------------RSFKHLAFGFGVRQCLG 448

  Fly   473 KRIVDLEMELTVANLVRNFHIEYNYSTEKPYKCRFLYKPN 512
            :|:.:.||.|.:.:::::||:|.....:.....||:..|:
Mouse   449 RRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	133/452 (29%)
Cyp11b1	NP_001028401.3	cytochrome_P450	72..495	CDD:477761	134/457 (29%)