Protein Alignment Cyp12c1 and Cyp27a1

DIOPT Version :9

• Sequence 1: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_077226.2
• Gene: Cyp27a1 / 104086
• MGIID: 88594
• Length: 533
• Species: Mus musculus
• Alignment Length: 512
• Identity: 133/512 - (25%)
• Similarity: 242/512 - (47%)
• Gaps: 63/512 - (12%)

  Fly     9 GLRANSQLAA-------TRNPDASSYVQQLESEWEGAKPFTELPGPTRWQ-LFRGFQKGGEYHQL 65
            |.||.:.:.|       |..|.......:|.|.       .||||....| ||:.|.:|   :.|
Mouse    27 GARAKATIPAALQAQESTEGPGTGQDRPRLRSP-------AELPGTGTLQFLFQLFLQG---YVL 81

  Fly    66 GMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYRNKRKD 130
            .:.|:..|.|.::|.:....  ||..:.|...:....|:|.|.||::|:|...:....:|:.:..
Mouse    82 HLPDLQVLNKTKYGPMWTTS--FGTYTNVNLASAPLLEQVMRQEGKYPIRDHMDQWKDHRDHKGL 144

  Fly   131 EFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIR-DKESQEVP 193
            .:     |:| ..|.:|...|.|:...|::....|:|...:..|...|:.|:.::| :.||.:..
Mouse   145 TY-----GIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQV 204

  Fly   194 GDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMD-----SFFDLGVRPSLY 253
            .|..:.:.||..|::..:..::.:|.|:.:.|...|: ..:::.::..     :|.....||.|
Mouse   205 PDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDTAA-FIRSVAIMFQNSVYITFLPKWTRPLL- 267

  Fly   254 RYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSND-------HKSVLEQLLQIDRK 311
                 |.:|::....|.||......:::.::.:..:..:...:.       |..:..:||.....
Mouse   268 -----PFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVSGYLHFLLTNELLSTQET 327

  Fly   312 LAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKL----TSLHSEFTVEDMKSL 372
            :...  .::|:.||||||..::..|.:|:|:||.|:.|.:||...:    ...|.:|.     .:
Mouse   328 IGTF--PELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKDFA-----HM 385

  Fly   373 PYLRAVIKESLRLYPVTFGNAR-SAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPE 436
            |.|:|||||:||||||...|:| ....:..::|:..||.|:.::.:..:.:|..::|....|.|.
Mouse   386 PLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPH 450

  Fly   437 RWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHI 493
            ||||:|:.|...:     |:.|..:|||:|.|.|:|:||.:|||:|.::.||:.:.|
Mouse   451 RWLRKKEADNPGI-----LHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	123/469 (26%)
Cyp27a1	NP_077226.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..60		5/32 (16%)
		p450	82..527	CDD:278495	115/447 (26%)
		Sterol-binding. /evidence=ECO:0000255	386..400		10/13 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770