Protein Alignment Cyp12c1 and cyp24a1

DIOPT Version :10

• Sequence 1: NP_649052.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_012808417.2
• Gene: cyp24a1 / 100497429
• XenbaseID: XB-GENE-479201
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 141/507 - (27%)
• Similarity: 242/507 - (47%)
• Gaps: 63/507 - (12%)

  Fly     4 LTVKHGLRANSQLAATRNPDASSYVQQLESEWEGAK----PFTELPGPTRWQLFRG----FQKGG 60
            ::|:|.:           |.|::.....|.|.....    ....|||||:..:...    .:|||
 Frog    19 ISVQHSI-----------PTATAVCDLKEEELPAPSSCPHSLAALPGPTKLPILGSLLDILRKGG 72

  Fly    61 EYHQLGMDDVMRLYKKQFGDICLIP-GLF-----GMPSTVFTFNVETFEKVYRTEGQWPVRGGAE 119
            ...|   .:.:..|.||||.|..:. |.|     |.|..:        |.:||.|..:|.|...:
 Frog    73 LKRQ---HEALASYHKQFGKIFRMKLGSFDSVHIGAPCLL--------EALYREESNYPKRLEIK 126

  Fly   120 PVIHYRNKRKDEFFKNCMG-LFGNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIRE 183
            |...||:.|.:.:     | |...|.:|.:.|||....||:...|......:..|...|:.||..
 Frog   127 PWKAYRDYRDEAY-----GLLILEGKDWQRVRSAFQQKLMKPTEVGKLDTKINEVLVDFMKRIDS 186

  Fly   184 IRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEASKLFKNIEVLMDSFFDLGV 248
            :.|::.  ...|....:|..:.||:..|..::..|.| :.|...||......|:::|.:|..:.|
 Frog   187 VCDEDG--TIEDLYCELNKWSLESICLVLYEKRFGFL-QPNLGEEAQNFITAIKMMMSTFGLMMV 248

  Fly   249 RP-SLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQGDSNDHKSVLEQLLQIDRKL 312
            .| .|::.:.|..:|..:.|.|.||.|...::::   |:.:.||:| |.|....:....::.:|.
 Frog   249 TPVELHKSLNTKIWKDHTHAWDSIFKTAKCHIDR---RLTKLSSKG-SEDFLCTIYNDSKLSKKE 309

  Fly   313 AVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTSLHSEF-TVEDMKSLPYLR 376
            ......:||:|.|:||:.::...:.|:::||..|::|.||:.|.|  |..:. |.:|::::|||:
 Frog   310 MYATITEMLIGAVETTANSLLWAIFNISRNPHIQKKLLEEIESVL--LPDQVPTADDIRNMPYLK 372

  Fly   377 AVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEFIPERWLRR 441
            |.:|||:|:.|......|:...:.||..|.:||||.|.:.:..|..:...:....:|.|||||::
 Frog   373 ACLKESMRITPSIPFTTRTLDKETVLGDYVLPKGTVLTINSHVLGSNQECFDNWNQFRPERWLQQ 437

  Fly   442 KDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHI 493
            |:          .:|.|.::|||.|.|||:|:|:.:|:::||:..|:|.:.|
 Frog   438 KN----------TINPFAHVPFGIGKRMCIGRRLAELQLQLTLCWLIRKYEI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12c1	NP_649052.1	CYP24A1-like	76..516	CDD:410677	125/427 (29%)
cyp24a1	XP_012808417.2	CYP24A1	84..502	CDD:410738	125/428 (29%)