Protein Alignment Chmp1 and CHMP1B

DIOPT Version :10

• Sequence 1: NP_649051.3
• Gene: Chmp1 / 40036
• FlyBaseID: FBgn0036805
• Length: 203
• Species: Drosophila melanogaster
• Sequence 2: NP_065145.2
• Gene: CHMP1B / 57132
• HGNCID: 24287
• Length: 199
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 149/197 - (75%)
• Similarity: 169/197 - (85%)
• Gaps: 2/197 - (1%)

  Fly     4 SSMEKHLFNLKFAVKELERNSKKCEKEEKLEKAKAKKAIQKGNMDVARIHAENAIRQKNQAVNYL 68
            |:|||||||||||.|||.|::|||:||||.||||.|||||||||:||||||||||||||||||:|
Human     2 SNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFL 66

  Fly    69 RMSARVDAVASRVQSALTTRKVTGSMAGVVKAMDAAMKGMNLEKISSLMEKFESQFEDLDVQSSV 133
            ||||||||||:|||:|:|..|||.|||||||:|||.:|.|||||||:||:|||.|||.||||:..
Human    67 RMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQ 131

  Fly   134 MEGTMSDTVTTSVPQGDVDNLLQQVADEAGLELNMELPSGVQSQSVGASTAVSQEQDELTQRLAR 198
            ||.|||.|.|.:.||..||.|||::||||||:||||||.| |:.|||.|.| |.|||||:|||||
Human   132 MEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQG-QTGSVGTSVA-SAEQDELSQRLAR 194

  Fly   199 LR 200
            ||
Human   195 LR 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chmp1	NP_649051.3	Snf7	<42..172	CDD:460896	98/129 (76%)
CHMP1B	NP_065145.2	Snf7	11..164	CDD:460896	115/152 (76%)
		Interaction with IST1	132..156		14/23 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..199		23/32 (72%)
		Interaction with SPAST. /evidence=ECO:0000269|PubMed:15537668	174..199		18/24 (75%)
		Interaction with VTA1	180..199		14/18 (78%)
		Interaction with VPS4A, MITD1 and STAMBP. /evidence=ECO:0000269|PubMed:19129480	180..196		12/16 (75%)
		Interaction with VPS4B	183..199		12/14 (86%)
		MIT-interacting motif	186..196		8/9 (89%)