DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GNBP1 and GNBP3

DIOPT Version :9

Sequence 1:	NP_524142.2	Gene:	GNBP1 / 40034	FlyBaseID:	FBgn0040323	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_523986.2	Gene:	GNBP3 / 39020	FlyBaseID:	FBgn0040321	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	156/539 - (28%)
Similarity:	241/539 - (44%)	Gaps:	114/539 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CIGIL-LLIGFGCTTAYKIPTPTVELL-ETGFSVSIPDEEGVKVVAFNVNRNRNFTSFINEGQYN 67
            |:.:| ||:|   ...|::|...:::. ..||.||||||||:.:.||:...|..... :..|.:.
  Fly    13 CLQLLFLLLG---VQGYEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEG-LEAGTWA 73

  Fly    68 VRLTEPQNGRWTTNFSSVPLRSQDVLYLWTSVQHQKAVYQDLAQPLPVCNLGGEYRPRGCSPGDD 132
            ..:.:.:|||||.......|:..|.||.||.|     :|..|                |....|.
  Fly    74 RDIVKAKNGRWTFRDRITALKPGDTLYYWTYV-----IYNGL----------------GYREDDG 117

  Fly   133 DFTDDNQLSTEDSALEPTAPSVCEPSESQVSPQIGVSI---------------CKGQLLFEETFD 182
            .|..:.......|...|..|....|......|.|.:.:               |.|||:|.:.|:
  Fly   118 SFVVNGYSGNNASPHPPVVPVSTTPWTPPADPDIDIRLGCTTPKTEVNGAPTRCAGQLVFVDEFN 182

  Fly   183 --QLNESLWIHDVRLPLDSKDAEFVLYDGKAK----VHDGNLVIEP-LLWSSYRPDLSIANSRLD 240
              :|:.:.|..:.|.. ...|.||.:|...|.    :.:|::|:.. .:...::..   :...||
  Fly   183 AAKLDPNKWKAERRFS-GQPDYEFNVYVDDAPETLCLANGHVVLSTNTMKKQFKKG---SGESLD 243

  Fly   241 LSERCTGTHNRIKECILHSTGSGPSGIMPPIVTPRISTKETFAFQYGRIEIRAKLPKGDWIVPLL 305
            |.|:|||..| ..:|:  ..|...:..:||:||.:.|:|: |:|:|||:|:|||:|:..|:.|.:
  Fly   244 LGEKCTGQAN-THDCV--RNGRTLNDGLPPMVTAQFSSKD-FSFKYGRVEVRAKMPRAQWVTPQI 304

  Fly   306 LLEPLTEWYGQSGYESGQLRVALARGNSVLRMPRGKLVDGRSLYGGPVLSTD------------- 357
            .|:|....||...|.|||||:|..|       |.|..:|   |||..||..|
  Fly   305 WLQPRRPIYGVDDYRSGQLRIAYTR-------PNGGNLD---LYGAAVLFADEPLRSVKNCLKPG 359

  Fly   358 -AHQREDLWLSKRKISHFGDDFHTYSLDWSSNRLLFSVDGQ---VYGEMLNGFTE-------LDE 411
             .:..|| |         .|.||.|:|:|:...|.:.|||:   |.|.....|:|       |.:
  Fly   360 TGNNSED-W---------SDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQ 414

  Fly   412 NPRWKQGGPMAPFDKMFYISLGVSVGGFGDFVDHLRTATYEKPWANYHPQAKLQF----HQAQDQ 472
            ..:.::|..:||||:.||::.|:|||||.::...:      |||....|||:..|    .:.:|.
  Fly   415 AQKLEEGTGLAPFDQEFYLTFGLSVGGFNEYQHEI------KPWNERAPQAQKAFWKEVKKIRDH 473

  Fly   473 WLPTWKQPALKIDYVRVFA 491
            ||   .:..:|||||:|::
  Fly   474 WL---DEGHMKIDYVKVYS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNBP1	NP_524142.2	CBM39	21..126	CDD:292510	29/105 (28%)
GNBP1	NP_524142.2	GH16_beta_GRP	175..491	CDD:185688	109/350 (31%)
GNBP3	NP_523986.2	CBM39	27..132	CDD:292510	33/126 (26%)
GNBP3	NP_523986.2	GH16_beta_GRP	175..489	CDD:185688	109/350 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105633at50557
OrthoFinder	1	1.000	-	-		FOG0006727
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950