Protein Alignment MYPT-75D and PPP1R16A

DIOPT Version :10

• Sequence 1: NP_649049.1
• Gene: MYPT-75D / 40032
• FlyBaseID: FBgn0036801
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_047278287.1
• Gene: PPP1R16A / 84988
• HGNCID: 14941
• Length: 602
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 211/580 - (36%)
• Similarity: 280/580 - (48%)
• Gaps: 132/580 - (22%)

  Fly    24 EHADLVAEMQTVESLPTHERLQLARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNG 88
            ||.:|:|||..|..:.|.|||:.|:.|||||:|:..|.:||           |.|..|.|....
Human     3 EHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKE-----------AQGKKGPGERPR- 55

  Fly    89 LMNGNGDTTHHFRHANGSGTLSGRRHISFENSVVLLEAASRNDMPEVAAL--------------- 138
                        :.|...|.|   :.:.|..||||||||:|||:.|..|:
Human    56 ------------KEAASQGLL---KQVLFPPSVVLLEAAARNDLEEAPAVWVPLLVLWSLGGRGT 105

  Fly   139 -----------------------------------------------------------LQHGIT 144
                                                                       |..|::
Human   106 VVALETPSCLPPEQRVKRSRQCLACIFPCGQEPSREAWRQREEAEGAMVHRELWEVRQFLGSGVS 170

  Fly   145 PDAANEDGLTAMHQACIDNNVEMLQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGA 209
            ||.||||||||:||.|||:..||:|.|||.|||::|.||:.|||||||||||||.||.:||..||
Human   171 PDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGA 235

  Fly   210 NLLAVNTDGNMPYDLCDDEKTLDFIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLE 274
            |||||||||||||||||||:|||.:|..||.||:||:.|:..|:..|..||.|:....:.|.||.
Human   236 NLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLH 300

  Fly   275 EPDYQCATPLHIAAANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADL 339
            .|....||.||:|||||:......|||...::.|.|:|.|.|:||||.||.:.::|:|...||||
Human   301 APLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADL 365

  Fly   340 NVRNKDDETPSDICEDPEIRERIEQLKTEQESKRLAEAQRRRV--RRSQSNNTRAQSVRRTSLRD 402
            |.::..||||.|:|.|.|:|.::.:||.:.::...|::::|.:  ||:.|..:|.:.|||.||..
Human   366 NAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQ 430

  Fly   403 KTLTTKKDAVEETRLRLQAQEATDSEAPSSAGDPLTNGY-----GYGNNNGEKRPSTGSSNGQPL 462
            :|...:|...:|. :..|....|..|.|....|..|...     ...:|....||..|...|.|:
Human   431 RTDLYRKQHAQEA-IVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 494

  Fly   463 PH--SKSAD--------ALDNAT-------------AALSANATHSYPSRRPPDGRENDE 499
            .|  ||..|        .||:.|             |.|......:...|.||:|.|:.|
Human   495 RHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPE 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_649049.1	ANKYR	123..366	CDD:440430	136/316 (43%)
		ANK repeat	123..149	CDD:293786	14/99 (14%)
		ANK repeat	151..182	CDD:293786	20/30 (67%)
		ANK repeat	184..215	CDD:293786	23/30 (77%)
		ANK repeat	217..310	CDD:293786	45/92 (49%)
		Ank_4	<259..300	CDD:372654	16/40 (40%)
		ANK repeat	312..343	CDD:293786	16/30 (53%)
PPP1R16A	XP_047278287.1	ANKYR	<152..401	CDD:440430	128/248 (52%)
		ANK repeat	177..208	CDD:293786	20/30 (67%)
		ANK repeat	210..241	CDD:293786	23/30 (77%)
		ANK repeat	305..336	CDD:293786	13/30 (43%)
		ANK repeat	338..368	CDD:293786	16/29 (55%)