DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and ppp1r16b

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_001340092.6	Gene:	ppp1r16b / 799771	ZFINID:	ZDB-GENE-131127-294	Length:	532	Species:	Danio rerio

Alignment Length:	510	Identity:	208/510 - (40%)
Similarity:	286/510 - (56%)	Gaps:	58/510 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HADLVAEMQTVESLPTHERLQLARLRRAQQLKLSRQKDKEWA---KLQRAKGNTASGGSGTGSLG 86
            |.:|::|:|.::.:|:.|||:.|:.||.|||       |.||   |..:.|...|....|.|||
Zfish     4 HLELLSELQQLDKVPSLERLRAAQKRRTQQL-------KRWAVYEKEMQNKKRKADKRRGPGSL- 60

  Fly    87 NGLMNGNGDTTHHFRHANGSGTLSGRRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANED 151
                                  :..||.:||..||.||||::|||..||..||::.::||.:|||
Zfish    61 ----------------------VENRRRVSFAASVALLEASARNDPDEVRYLLKNNLSPDLSNED 103

  Fly   152 GLTAMHQACIDNNVEMLQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNT 216
            ||||:||.||||..||:|:||.:||.|:|||::.||||||||||||..||:|||:|||:|||||:
Zfish   104 GLTALHQCCIDNYEEMVQILLTHGATVNAQDNELWTPLHAAATCGHTGLVKILIQHGADLLAVNS 168

  Fly   217 DGNMPYDLCDDEKTLDFIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLEEPDYQCA 281
            |||||||||:|:.|||.||..||.||:|||:|:|||::.||.||.|:.::.:.|.|:...|.|.|
Zfish   169 DGNMPYDLCEDDPTLDIIETAMANRGITQEMINETRAAVERSMLGDIQKILQEGADVNHHDSQGA 233

  Fly   282 TPLHIAAANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDD 346
            |.||||:||||.:..|.||:.....|..|.|.|||:|||||||.::|.|:|...||.||.:...:
Zfish   234 TLLHIASANGYTQAAELLLDAGARSDMRDSDGWTPLHAAACWGQVQVAELLVSHGASLNAKTYME 298

  Fly   347 ETPSDICEDPEIRERIEQLKTEQE--SKRLAEAQRRRVRRSQSNNTRAQSVRRTSLRDKTLTTKK 409
            |||.|:|||.|.|..:.:||.:.:  .|...:.:....||:.|..:|.:.|||.||.|:....:|
Zfish   299 ETPIDLCEDEEFRNHLLELKHKHDIIMKSQLKHKTSLCRRTSSAGSRGKVVRRASLSDRHNLCRK 363

  Fly   410 DAVEETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQ------PLPHSKSA 468
            :...|..:....:|..:.|..|..    .|.:......|.:.|.....:||      |.|:....
Zfish   364 EYQTEAIVWRGGREKEERERESDQ----ENSHTMQPTEGPQSPGILKDSGQNGCISSPSPNGDPL 424

  Fly   469 DALDNATAALSANATHSYPSRRPPDGRENDELLRLKAAGAAGEMQRATSAAAVIL 523
            ...|..|..:            |.|...:.|..:|||. ...|:::..||||..|
Zfish   425 TPPDPMTPPV------------PGDPVTSAEEPKLKAQ-TLSELKKQRSAAAAKL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	60/91 (66%)
		ANK repeat	123..149	CDD:293786	13/25 (52%)
		ANK	146..332	CDD:238125	113/185 (61%)
		ANK repeat	151..182	CDD:293786	20/30 (67%)
		ANK repeat	184..215	CDD:293786	23/30 (77%)
		ANK repeat	217..310	CDD:293786	49/92 (53%)
		Ank_4	282..332	CDD:290365	27/49 (55%)
		ANK repeat	312..343	CDD:293786	18/30 (60%)
		Ank_4	314..>353	CDD:290365	21/38 (55%)
ppp1r16b	XP_001340092.6	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2323
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258197at33208
OrthoFinder	1	1.000	-	-		FOG0003042
OrthoInspector	1	1.000	-	-		otm26328
orthoMCL	1	0.900	-	-		OOG6_106248
Panther	1	1.100	-	-	O	PTHR24186
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3610
SonicParanoid	1	1.000	-	-		X2029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930