DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and Ppp1r16b

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001178001.1	Gene:	Ppp1r16b / 680616	RGDID:	1589460	Length:	568	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	195/461 - (42%)
Similarity:	270/461 - (58%)	Gaps:	53/461 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HADLVAEMQTVESLPTHERLQLARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGL 89
            |.||:.|:|.:|.:||.|||:.|:.||||||       |:||:.::
  Rat     4 HVDLLTELQLLEKVPTLERLRAAQKRRAQQL-------KKWAQYEQ------------------- 42

  Fly    90 MNGNGDTTHHFR-HANGSGTLSGRRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGL 153
                 |..|..| |.....|...|:.:|||.||.||||:.|||..||...|::.::||..|||||
  Rat    43 -----DLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGL 102

  Fly   154 TAMHQACIDNNVEMLQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDG 218
            ||:||.||||..|:::|||.:||||:|:|::.||||||||||||:.||:||:::||:|||||:||
  Rat   103 TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDG 167

  Fly   219 NMPYDLCDDEKTLDFIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLEEPDYQCATP 283
            |||||||:||.|||.||..||.:|:|||.|:|.|::.|:.|:.|:..:...|.||:..|.|.||.
  Rat   168 NMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATL 232

  Fly   284 LHIAAANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDET 348
            ||||.||||:|..|.||:..|.||..|.|.|.|:||||.||.:.:.|:|...||.|:.|...||.
  Rat   233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEM 297

  Fly   349 PSDICEDPEIRERIEQLKTEQESKRLAEAQRRR----VRRSQSNNTRAQSVRRTSLRDKTLTTKK 409
            |.|:||:.|.:..:.:||.:.:.  :.::|.|.    .||:.|..:|.:.|||.||.|:|...:|
  Rat   298 PIDLCEEEEFKVLLLELKHKHDV--IMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK 360

  Fly   410 DAVEETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNNNGEKRPS-TGSSNGQPLPHSKSADALDN 473
            :...|..|..|.         |:|.:..|:.|     ||:.|.: |...|..|.|..:....|..
  Rat   361 EYEGEAILWQQR---------SAAEEQRTSTY-----NGDIRETRTDQENKDPNPRLEKPVLLSE 411

  Fly   474 ATAALS 479
            .:..:|
  Rat   412 FSTKIS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	56/91 (62%)
		ANK repeat	123..149	CDD:293786	12/25 (48%)
		ANK	146..332	CDD:238125	108/185 (58%)
		ANK repeat	151..182	CDD:293786	20/30 (67%)
		ANK repeat	184..215	CDD:293786	21/30 (70%)
		ANK repeat	217..310	CDD:293786	50/92 (54%)
		Ank_4	282..332	CDD:290365	27/49 (55%)
		ANK repeat	312..343	CDD:293786	14/30 (47%)
		Ank_4	314..>353	CDD:290365	18/38 (47%)
Ppp1r16b	NP_001178001.1	PHA03095	71..>301	CDD:222980	127/229 (55%)
		ANK repeat	71..98	CDD:293786	12/26 (46%)
		Ank_2	72..164	CDD:403870	56/91 (62%)
		ANK repeat	100..131	CDD:293786	20/30 (67%)
		ANK repeat	133..164	CDD:293786	21/30 (70%)
		ANK repeat	166..259	CDD:293786	50/92 (54%)
		ANK repeat	261..292	CDD:293786	14/30 (47%)
		ANK repeat	294..318	CDD:293786	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335574
Domainoid	1	1.000	72	1.000	Domainoid score	I9124
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2296
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258197at33208
OrthoFinder	1	1.000	-	-		FOG0003042
OrthoInspector	1	1.000	-	-		otm44738
orthoMCL	1	0.900	-	-		OOG6_106248
Panther	1	1.100	-	-	O	PTHR24186
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2029
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760