DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and Espn

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_038966608.1	Gene:	Espn / 56227	RGDID:	620652	Length:	887	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	180/789 - (22%)
Similarity:	264/789 - (33%)	Gaps:	224/789 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGSGTLSGRRHISF 117
            |.::.:|:.|.:..:...|          .|.||..|.:.......|  ||..||.|...|::..
  Rat     5 QAMQAARRGDLDVLRSLHA----------AGLLGPSLRDPLDALPVH--HAARSGKLHCLRYLVE 57

  Fly   118 ENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEMLQ-LLLEYGANVDAQ 181
            |   |.|.|.||                 |.|  |.|..|.|.....:..|| ||.:.|..|..:
  Rat    58 E---VALPAVSR-----------------ARN--GATPAHDAAATGYLSCLQWLLTQGGCRVQEK 100

  Fly   182 DSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTD-GNMPYDLCDDEKTL--------DFIEGE 237
            |:...|.||.||..||.::|..|:..|....|:.|| |.:|......:..|        .:.||.
  Rat   101 DNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGV 165

  Fly   238 MAQRG----------------VTQELIDETRSSTERIMLRD----LMELARTGGD---------- 272
            .||..                ||:.|:.|. |:...:..:|    |...|:.|.:
  Rat   166 NAQTNNGATPLYLACQEGHLEVTKYLVQEC-SADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFA 229

  Fly   273 ---LEEPDYQCATPLHIAAANGYVRVVEFLLEQHVNVDAMDKDLW--TPVHAAACWGHLEVLEML 332
               ..|.|:..||.:|.||:.|:.:|:.:||.....:   .:|||  ||:|.||..|.||..::|
  Rat   230 DVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEI---SQDLWGGTPLHDAAENGELECCQIL 291

  Fly   333 AQCGADLNVRNKDDETPSDICEDPEIRERIEQLKTEQ----ESKRLA-------EAQRRRVRRSQ 386
            |..||.|:||:.|..|.:|:.:..........|:|.|    |.:.|:       ||::.....|.
  Rat   292 AVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSS 356

  Fly   387 SNNTRAQSVRRTSLRDKTLTTKKDAVEETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNN----- 446
            .|.|.:.......|...|.|            |...::..|...||.|...|.|.....:
  Rat   357 PNTTMSVQPPNFDLGSPTST------------LSNYDSCSSSHSSSKGQRSTRGVPGARSSDLQS 409

  Fly   447 -----NGEKRPSTGSSNGQPLPHSKSADALDNATAALSANATHSYPSRRPPDGRENDELLRLKAA 506
                 |.|.|...|..:..|.|...|..........|.. ....||:..||.|...|.:.
  Rat   410 YMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPP-PPPGYPAPNPPVGLHLDNIY----- 468

  Fly   507 GAAGEMQRATSAAAVILTEKGTAASAEAVQIQSSKEAANGKINVQVTVLVDTNSTHHHQQHQQQQ 571
                 ||              |......|::.|.|:              ::.:.|...:...|.
  Rat   469 -----MQ--------------TKNKLRHVEVDSLKK--------------ESKACHPKVEPNDQF 500

  Fly   572 QQQQQH------HHQQHVLLLQQHQQLQQHQQQQQQQQQQQHVALDGYSATLANLKKQRSLSRTA 630
            .|....      ..|...||.|..:.|.:|....::|...               :||||.|:..
  Rat   501 AQPSSGDGYSGLRRQDSGLLRQDSELLLRHNTGLRRQDSD---------------RKQRSFSKQP 550

  Fly   631 NVLNTFELSSQTASNAHPIAAANATTTNGSV-------LGAGGSSSNNNNNLS-----------T 677
            :..:.:....:  |...|:||......:..|       .|..||:..::::||           .
  Rat   551 STGDYYRQLGR--SPGEPLAARPGMAHSEEVRVHQPAPAGCTGSNPVSHSSLSGPSAPPQAALLP 613

  Fly   678 SNNNNNG------------------------SAPISTQPTLGHMGAGSVLSDFEGSSPAGS--SL 716
            .|:.:||                        |:| ...|.|...|||:.......||..||  |.
  Rat   614 GNHVHNGCSADSKASRELPPPPPPPPLPEALSSP-PPAPPLPIEGAGAACGQRRSSSSTGSTKSF 677

  Fly   717 NKFSGITGD 725
            |..|. |||
  Rat   678 NMMSP-TGD 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	28/92 (30%)
		ANK repeat	123..149	CDD:293786	5/25 (20%)
		ANK	146..332	CDD:238125	64/230 (28%)
		ANK repeat	151..182	CDD:293786	10/31 (32%)
		ANK repeat	184..215	CDD:293786	11/30 (37%)
		ANK repeat	217..310	CDD:293786	28/134 (21%)
		Ank_4	282..332	CDD:290365	19/51 (37%)
		ANK repeat	312..343	CDD:293786	17/32 (53%)
		Ank_4	314..>353	CDD:290365	19/40 (48%)
Espn	XP_038966608.1	ANK repeat	39..67	CDD:293786	13/49 (27%)
		Ank_2	41..127	CDD:403870	35/109 (32%)
		ANK repeat	69..101	CDD:293786	11/33 (33%)
		ANK repeat	103..135	CDD:293786	11/31 (35%)
		Ank_2	108..202	CDD:403870	24/94 (26%)
		ANK repeat	137..169	CDD:293786	6/31 (19%)
		ANK repeat	171..202	CDD:293786	5/31 (16%)
		Ank_2	176..266	CDD:403870	20/90 (22%)
		ANK repeat	205..237	CDD:293786	5/31 (16%)
		ANK repeat	239..269	CDD:293786	9/32 (28%)
		Ank_2	244..324	CDD:403870	28/82 (34%)
		ANK repeat	271..302	CDD:293786	15/30 (50%)
		WH2	682..707	CDD:396675	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000