DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYPT-75D and PPP1R12C

DIOPT Version :10

Sequence 1:NP_649049.1 Gene:MYPT-75D / 40032 FlyBaseID:FBgn0036801 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_060077.1 Gene:PPP1R12C / 54776 HGNCID:14947 Length:782 Species:Homo sapiens


Alignment Length:523 Identity:153/523 - (29%)
Similarity:240/523 - (45%) Gaps:104/523 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 ARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGSGTLSG 111
            ||.||.:||       ::|       |..|....|.|.                |.|        
Human    18 ARERRREQL-------RQW-------GARAGAEPGPGE----------------RRA-------- 44

  Fly   112 RRHISFENSVVLLEAASRNDMPEVAALLQHG-------ITP----------DAANEDGLTAMHQA 159
             |.:.||.:...|.|.:..|:.|...:|:..       :.|          |:.|.||::|:|||
Human    45 -RTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQA 108

  Fly   160 CIDNNVEMLQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDL 224
            |||.|:|:::.|:|.||.|:..|::.|||||.||:||:|::.|.|:.||||:.|||:||::|.||
Human   109 CIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDL 173

  Fly   225 CDDEKTLDFIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLEEPDY--QCATPLHIA 287
            .:.:.....::.|:|:|||.   ::..:.:.|.::|.| ......||.:.|..:  ..|:.||:|
Human   174 AESDAMEGLLKAEIARRGVD---VEAAKRAEEELLLHD-TRCWLNGGAMPEARHPRTGASALHVA 234

  Fly   288 AANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDI 352
            ||.||:.|:..||:...:.:..|.|.|||:||||.||..:...:||:.|..::......:.|.|:
Human   235 AAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDL 299

  Fly   353 CEDPEIRERIEQLKTEQESKR-LAEAQRRRVRRSQ---SNNTRAQSVRRTSLRDKTLTTKKDAVE 413
            . |.|:...:|:|..:||..| ..||.:.|.:..|   |:..|..||.|.|.|:|          
Human   300 A-DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREK---------- 353

  Fly   414 ETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNNN------GEKRPSTGSSNGQPLPHSKSADALD 472
                 :..|:.:....|..||.|.......|...      .|.|...|.|: .|.|..||...|:
Human   354 -----ISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS-PPHPSPKSPVQLE 412

  Fly   473 NA--TAALSANATHSYPSRRPPDGRENDELLRLKAAGAAGE-MQRATSAAAVILTEKGTAASAEA 534
            .|  :.......|.|..:..||:        |..|.||.|. :||:.|::.:    :||:..|:.
Human   413 EAPFSRRFGLLKTGSSGALGPPE--------RRTAEGAPGAGLQRSASSSWL----EGTSTQAKE 465

  Fly   535 VQI 537
            :::
Human   466 LRL 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYPT-75DNP_649049.1 ANKYR 123..366 CDD:440430 90/261 (34%)
ANK repeat 123..149 CDD:293786 7/42 (17%)
ANK repeat 151..182 CDD:293786 16/30 (53%)
ANK repeat 184..215 CDD:293786 17/30 (57%)
ANK repeat 217..310 CDD:293786 27/94 (29%)
Ank_4 <259..300 CDD:372654 14/42 (33%)
ANK repeat 312..343 CDD:293786 13/30 (43%)
PPP1R12CNP_060077.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43 11/54 (20%)
ANKYR 52..322 CDD:440430 94/274 (34%)
ANK repeat 100..131 CDD:293786 16/30 (53%)
ANK 1. /evidence=ECO:0000255 100..129 16/28 (57%)
ANK repeat 133..164 CDD:293786 17/30 (57%)
ANK 2. /evidence=ECO:0000255 133..162 16/28 (57%)
ANK repeat 226..257 CDD:293786 11/30 (37%)
ANK 3. /evidence=ECO:0000255 226..255 11/28 (39%)
ANK 4. /evidence=ECO:0000255 259..288 13/28 (46%)
ANK repeat 259..283 CDD:293786 12/23 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..686 45/181 (25%)
PTZ00449 <371..>619 CDD:185628 27/111 (24%)
IPD_PPP1R12C 524..577 CDD:412020
PRKG1_interact 683..782 CDD:464927
Blue background indicates that the domain is not in the aligned region.

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