DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYPT-75D and PPP1R12C

DIOPT Version :9

Sequence 1:NP_001262018.1 Gene:MYPT-75D / 40032 FlyBaseID:FBgn0036801 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_060077.1 Gene:PPP1R12C / 54776 HGNCID:14947 Length:782 Species:Homo sapiens


Alignment Length:523 Identity:153/523 - (29%)
Similarity:240/523 - (45%) Gaps:104/523 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 ARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGSGTLSG 111
            ||.||.:||       ::|       |..|....|.|.                |.|        
Human    18 ARERRREQL-------RQW-------GARAGAEPGPGE----------------RRA-------- 44

  Fly   112 RRHISFENSVVLLEAASRNDMPEVAALLQHG-------ITP----------DAANEDGLTAMHQA 159
             |.:.||.:...|.|.:..|:.|...:|:..       :.|          |:.|.||::|:|||
Human    45 -RTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQA 108

  Fly   160 CIDNNVEMLQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDL 224
            |||.|:|:::.|:|.||.|:..|::.|||||.||:||:|::.|.|:.||||:.|||:||::|.||
Human   109 CIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDL 173

  Fly   225 CDDEKTLDFIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLEEPDY--QCATPLHIA 287
            .:.:.....::.|:|:|||.   ::..:.:.|.::|.| ......||.:.|..:  ..|:.||:|
Human   174 AESDAMEGLLKAEIARRGVD---VEAAKRAEEELLLHD-TRCWLNGGAMPEARHPRTGASALHVA 234

  Fly   288 AANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDI 352
            ||.||:.|:..||:...:.:..|.|.|||:||||.||..:...:||:.|..::......:.|.|:
Human   235 AAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDL 299

  Fly   353 CEDPEIRERIEQLKTEQESKR-LAEAQRRRVRRSQ---SNNTRAQSVRRTSLRDKTLTTKKDAVE 413
            . |.|:...:|:|..:||..| ..||.:.|.:..|   |:..|..||.|.|.|:|          
Human   300 A-DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREK---------- 353

  Fly   414 ETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNNN------GEKRPSTGSSNGQPLPHSKSADALD 472
                 :..|:.:....|..||.|.......|...      .|.|...|.|: .|.|..||...|:
Human   354 -----ISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS-PPHPSPKSPVQLE 412

  Fly   473 NA--TAALSANATHSYPSRRPPDGRENDELLRLKAAGAAGE-MQRATSAAAVILTEKGTAASAEA 534
            .|  :.......|.|..:..||:        |..|.||.|. :||:.|::.:    :||:..|:.
Human   413 EAPFSRRFGLLKTGSSGALGPPE--------RRTAEGAPGAGLQRSASSSWL----EGTSTQAKE 465

  Fly   535 VQI 537
            :::
Human   466 LRL 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYPT-75DNP_001262018.1 Ank_2 123..215 CDD:289560 42/108 (39%)
ANK repeat 123..149 CDD:293786 7/42 (17%)
ANK 146..332 CDD:238125 76/187 (41%)
ANK repeat 151..182 CDD:293786 16/30 (53%)
ANK repeat 184..215 CDD:293786 17/30 (57%)
ANK repeat 217..310 CDD:293786 27/94 (29%)
Ank_4 282..332 CDD:290365 21/49 (43%)
ANK repeat 312..343 CDD:293786 13/30 (43%)
Ank_4 314..>353 CDD:290365 14/38 (37%)
PPP1R12CNP_060077.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43 11/54 (20%)
ANK 95..279 CDD:238125 76/187 (41%)
ANK repeat 100..131 CDD:293786 16/30 (53%)
ANK 1. /evidence=ECO:0000255 100..129 16/28 (57%)
Ank_2 105..257 CDD:289560 60/155 (39%)
ANK repeat 133..164 CDD:293786 17/30 (57%)
ANK 2. /evidence=ECO:0000255 133..162 16/28 (57%)
ANK repeat 226..257 CDD:293786 11/30 (37%)
ANK 3. /evidence=ECO:0000255 226..255 11/28 (39%)
Ank_5 246..300 CDD:290568 18/53 (34%)
ANK 4. /evidence=ECO:0000255 259..288 13/28 (46%)
ANK repeat 259..283 CDD:293786 12/23 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..686 45/181 (25%)
FAM196 <424..>624 CDD:291917 15/57 (26%)
PRKG1_interact 683..781 CDD:292521
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0505
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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