DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYPT-75D and PPP1R12B

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_016856831.1	Gene:	PPP1R12B / 4660	HGNCID:	7619	Length:	1059	Species:	Homo sapiens

Alignment Length:	728	Identity:	187/728 - (25%)
Similarity:	318/728 - (43%)	Gaps:	122/728 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ERLQLARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGS 106
            :|.:.||:|||:||       :.|                .|||          |........|:
Human    10 KRAESARMRRAEQL-------RRW----------------RGSL----------TEQEPAERRGA 41

  Fly   107 G----TLSGRRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEM 167
            |    |..|...:.||:..|.|.|.|..|..||..||..|...:..|.|||||:||||||.|::|
Human    42 GRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDM 106

  Fly   168 LQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLD 232
            ::.|:|..|||:.||::.||||||||:||:|.:....|.|||::..||::|.:|.||.::....|
Human   107 VKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD 171

  Fly   233 FIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTG--GDLEEPDYQCATPLHIAAANGYVRV 295
            .:..::.::||.   ::::|...|:.||:|..:...:|  .|:.:. ...||.||:|||.||..|
Human   172 LLLEQVKKQGVD---LEQSRKEEEQQMLQDARQWLNSGKIEDVRQA-RSGATALHVAAAKGYSEV 232

  Fly   296 VEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICEDPEIRE 360
            :..|::....::..|.|.|||:||||.||..|...:||:...|:::|||..:||.|:. |..:.|
Human   233 LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA-DEGLVE 296

  Fly   361 RIEQLKTEQESKRLAEAQRRRVRRSQSNNTRAQSVRRTSLRDKTL----TTKKDAVEETRLRLQA 421
            .:|.|:.:|...|..:..|.::..|..|:.......:.  ::|.|    |.|...:||......:
Human   297 HLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKN--KEKMLYEEETPKSQEMEEENKESSS 359

  Fly   422 QEATDSEAPSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADALDNATAALSANATHSY 486
            ..:.:.|....|.:..|      ....:|:|....::.    :|:|..::.....|.:.|...:.
Human   360 SSSEEEEGEDEASESET------EKEADKKPEAFVNHS----NSESKSSITEQIPAPAQNTFSAS 414

  Fly   487 PSRR-----------PPDGRENDELLRLKAAGAAGEMQRATSAAAVILTEKGTA--ASAEAVQIQ 538
            .:||           |.|...:...|.|:..|:...:....::...| .::|::  .|:.:.:|.
Human   415 SARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPI-RDRGSSIYRSSSSPRIS 478

  Fly   539 S-----SKEAANGKINVQVTVLVDTNSTHHHQQHQQQQQQQQQHHHQQHVLLLQQHQQLQQ-HQQ 597
            :     .||..| |..:........|||         ...:::.:.:..|.|::.....:| .:.
Human   479 ALLDNKDKEREN-KSYISSLAPRKLNST---------SDIEEKENRESAVNLVRSGSYTRQLWRD 533

  Fly   598 QQQQQQQQQHVALDGYSATLANLKKQRSLSRTANVLNTFELSSQTASNAHPIAAANATTTNGSVL 662
            :.:..:..|.:|...|.:|..   |..|..|:::..:.:..:::.:|.|.......::|:.||..
Human   534 EAKGNEIPQTIAPSTYVSTYL---KSASFGRSSDPTSPYISANRNSSPATSPITIGSSTSRGSQW 595

  Fly   663 GAGGSSSNNNNNLSTSNNNNNGSAPISTQPTLGHMGAGSVLSDFEGSSPAGSSLNKFSGITGDVV 727
            ....|.                .||||         |.:..|...|.:|..|.    :..|.:..
Human   596 QPASSC----------------PAPIS---------ANTTASVHHGRTPHKSQ----ADTTAEKT 631

  Fly   728 TDSTSSSRRCCVL 740
            .|:.|||...||:
Human   632 ADNVSSSTPLCVI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	45/91 (49%)
		ANK repeat	123..149	CDD:293786	9/25 (36%)
		ANK	146..332	CDD:238125	75/187 (40%)
		ANK repeat	151..182	CDD:293786	18/30 (60%)
		ANK repeat	184..215	CDD:293786	15/30 (50%)
		ANK repeat	217..310	CDD:293786	25/94 (27%)
		Ank_4	282..332	CDD:290365	22/49 (45%)
		ANK repeat	312..343	CDD:293786	14/30 (47%)
		Ank_4	314..>353	CDD:290365	19/38 (50%)
PPP1R12B	XP_016856831.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810