DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYPT-75D and PPP1R12A

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001137357.1	Gene:	PPP1R12A / 4659	HGNCID:	7618	Length:	1030	Species:	Homo sapiens

Alignment Length:	683	Identity:	177/683 - (25%)
Similarity:	298/683 - (43%)	Gaps:	114/683 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEMLQLLLEYGANVD 179
            :.|::..|.|.|.|..|..||..||..|...:.||.|||||:||||||:||:|::.|:|.|||::
Human    36 VKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANIN 100

  Fly   180 AQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLDFIEGEMAQRGVT 244
            ..|::.|.||||||:||:|::...||..||::.|||::|:.|.|:.::|...:.::.|:.::||.
Human   101 QPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165

  Fly   245 QELIDETRSSTERIMLRDLMEL-----------ARTGGDLEEPDYQCATPLHIAAANGYVRVVEF 298
               |:..|...|||||||..:.           |::||          |.||:|||.||..|::.
Human   166 ---IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG----------TALHVAAAKGYTEVLKL 217

  Fly   299 LLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICEDPEIRERIE 363
            |::...:|:..|.|.|||:||||.||..|...:|.....|:.:.||..:|..|:. |.:|...:|
Human   218 LIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLE 281

  Fly   364 QLKTEQESKRLAEAQRRRVR----RSQSNNTRAQSVRRTSLRDKTLTTKKDAVEE-----TRLRL 419
            :|   |:.:.|..:::|..:    .|.:|....||       .||...|:..:.|     :|:..
Human   282 EL---QKKQNLLHSEKRDKKSPLIESTANMDNNQS-------QKTFKNKETLIIEPEKNASRIES 336

  Fly   420 QAQEATDSEAPSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADALDNATAAL------ 478
            ..||..|.|......:...:......::.|....|..:  :||....:|:......|.:
Human   337 LEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT--KPLASVTNANTSSTQAAPVAVTTPT 399

  Fly   479 --SANATHSYPSRR---------PPDGRENDE-----LLRLKAAGAAGEMQRATSAAAVILTEKG 527
              |..||.:.|.::         |.:....||     .|.|:..|:.|.:...| |:.....||.
Human   400 VSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEIT-ASKEGQKEKD 463

  Fly   528 TAA---SAEAVQIQSSKEAANGKINVQVTVLVDTNSTHHHQQHQQQQQQQQQHHHQQHVLLLQQH 589
            ||.   ||.:.::.||.:....:.:.:.|.|.....|...:.......:::::         :..
Human   464 TAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKEN---------RDS 519

  Fly   590 QQLQQHQQQQQQQQQQQHVALDGYSATLANLKKQRSLSRTANVLNTFELSSQTASNAHPIAAAN- 653
            ..|:......:::.:.             :|||..|:    |..:|:..|.........:.:::
Human   520 SSLRTSSSYTRRKWED-------------DLKKNSSV----NEGSTYHKSCSFGRRQDDLISSSV 567

  Fly   654 -ATTTNGSVLGAGGSSSNNNNNLSTSNNNNNGSAPISTQ-PTLGHMGAGSVLSDFEGSSP----- 711
             :||:..:|..|.|...:..::.||:.....||:...|| .|...:.|.......:.|.|
Human   568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTI 632

  Fly   712 --------AGSSLNKFSGITGDVVTDSTSSSRR 736
                    |.:|....:..|...|:.:|....|
Human   633 PVAPTVVNAAASTTTLTTTTAGTVSSTTEVRER 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	46/91 (51%)
		ANK repeat	123..149	CDD:293786	9/25 (36%)
		ANK	146..332	CDD:238125	81/196 (41%)
		ANK repeat	151..182	CDD:293786	19/30 (63%)
		ANK repeat	184..215	CDD:293786	15/30 (50%)
		ANK repeat	217..310	CDD:293786	30/103 (29%)
		Ank_4	282..332	CDD:290365	23/49 (47%)
		ANK repeat	312..343	CDD:293786	13/30 (43%)
		Ank_4	314..>353	CDD:290365	16/38 (42%)
PPP1R12A	NP_001137357.1	KVKF motif	35..38		0/1 (0%)
		ANK 1	39..68		10/28 (36%)
		Ank_2	47..136	CDD:289560	45/88 (51%)
		ANK	67..252	CDD:238125	81/197 (41%)
		ANK repeat	72..103	CDD:293786	19/30 (63%)
		ANK 2	72..101		19/28 (68%)
		ANK repeat	105..136	CDD:293786	15/30 (50%)
		ANK 3	105..134		14/28 (50%)
		ANK repeat	138..229	CDD:293786	30/103 (29%)
		ANK 4	138..164		5/25 (20%)
		ANK 5	198..227		13/38 (34%)
		Ank_4	199..252	CDD:290365	25/62 (40%)
		ANK	226..>301	CDD:238125	25/78 (32%)
		ANK repeat	231..262	CDD:293786	13/30 (43%)
		ANK 6	231..260		13/28 (46%)
		Ank_4	232..280	CDD:290365	18/48 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..628		66/373 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..928		5/23 (22%)
		Interaction with ROCK2. /evidence=ECO:0000269\|PubMed:19131646	682..864
		PRKG1_interact	931..1029	CDD:292521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810