DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and Ppp1r12b

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_006529770.1	Gene:	Ppp1r12b / 329251	MGIID:	1916417	Length:	1053	Species:	Mus musculus

Alignment Length:	734	Identity:	190/734 - (25%)
Similarity:	318/734 - (43%)	Gaps:	135/734 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ERLQLARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGS 106
            :|.:.||.|||:||       :.|                .|||          |........|:
Mouse    10 KRAESARARRAEQL-------RRW----------------RGSL----------TEQEPAERQGA 41

  Fly   107 G----TLSGRRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEM 167
            |    |..|...:.||:..|.|.|.|..|..||..||..|...:..|.|||||:||||||.|::|
Mouse    42 GRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEVKKLLARGADINTVNVDGLTALHQACIDENLDM 106

  Fly   168 LQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLD 232
            ::.|:|..|||:.||::.||||||||:||:|.:....|.|||::..||::|.:|.||.::....|
Mouse   107 VKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFISHGASVGIVNSEGEVPSDLAEEPAMKD 171

  Fly   233 FIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTG--GDLEEPDYQCATPLHIAAANGYVRV 295
            .:..::.::||.   ::::|...|:.||:|..:...:|  .|:.:. ...||.||:|||.||..|
Mouse   172 LLLEQVKKQGVD---LEQSRKEEEQQMLQDARQWLNSGRIEDVRQA-RSGATALHVAAAKGYSEV 232

  Fly   296 VEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICEDPEIRE 360
            :..|::....::..|.|.|||:||||.||..|...:||:...|:::|||..:||.|:. |..:.|
Mouse   233 LRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA-DEGLVE 296

  Fly   361 RIEQLKTEQESKRLAEAQRRRVRRSQSNNTRAQSV---RRTSLRDKTLTTKKDAVEETRLRLQAQ 422
            .:|.|:.:|:..|..:..|.::..|..|:.....:   :...|.::.:...:|..||.:
Mouse   297 HLEMLQKKQDVLRSEKETRNKLIESDLNSKFQSGLFKNKEKMLYEEEIPKSQDTEEENK------ 355

  Fly   423 EATDSEAPSSAGDPLTNGYGYGNNNGEKRP--STGSSNGQ---------PLPHSKSADALDNATA 476
            |::.|.:....|:...: ........:|:|  :...||.:         |.|       ..|..:
Mouse   356 ESSSSSSEEEEGEDEVS-ESETEKEADKKPEATVNHSNSEIKSRIMEQIPAP-------AQNTFS 412

  Fly   477 ALSANATHSY--PSRRPPDGRENDELLRLKAAGAAGEMQRATSAAAVILTEKGTAASAEAVQIQS 539
            |.||....|.  .:..|.|...:...|.|:..|:..           :|:|  .|.|.||::.:.
Mouse   413 ASSARRLSSLFNKAEEPKDESPSSWRLGLRKTGSHN-----------MLSE--VANSREALRDRG 464

  Fly   540 SKEAANGKINVQVTVLVDTNSTHHHQQHQQQQQQQQQHHHQQHVLLLQQHQQLQQHQQQQQQQQQ 604
            | .......:.:::.|:|              .:.::..::.:..:|.. ::|......::::.:
Mouse   465 S-SIYRSSSSPRISALLD--------------DKDKERENKSYFSMLVP-RRLSSTSDIEEKENR 513

  Fly   605 QQHVALDGYSATLANLKKQRSLSRTANVLNTFELSSQTASNAHPIAAANATTTNGSVLGAGGSSS 669
            :..|.|            .||.|.|..:.......|:|...   ||.:..|:|.......|.||.
Mouse   514 ESAVNL------------VRSGSHTRQLWRDEAKGSETPQT---IAPSTYTSTYLKSASFGKSSD 563

  Fly   670 NNNNNLSTSNNNNNGSAPISTQPTLGHMGAGSVLSDFEGSSPAGSSLNKFSGI------------ 722
            ..:..:|.:.|::..::||    |:|...:.........|.||..|.|..:.:
Mouse   564 PTSPYISANRNSSPATSPI----TIGSSTSRGSQWQPASSCPAPVSTNTPAPVQHVRTPYKSQAD 624

  Fly   723 -TGDVVTDSTSSSRRCCVL 740
             |.:...||.|||...||:
Mouse   625 STAEKTADSVSSSTPLCVI 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	45/91 (49%)
		ANK repeat	123..149	CDD:293786	9/25 (36%)
		ANK	146..332	CDD:238125	75/187 (40%)
		ANK repeat	151..182	CDD:293786	18/30 (60%)
		ANK repeat	184..215	CDD:293786	15/30 (50%)
		ANK repeat	217..310	CDD:293786	25/94 (27%)
		Ank_4	282..332	CDD:290365	22/49 (45%)
		ANK repeat	312..343	CDD:293786	14/30 (47%)
		Ank_4	314..>353	CDD:290365	19/38 (50%)
Ppp1r12b	XP_006529770.1	PHA03095	61..>290	CDD:222980	94/232 (41%)
		Ank_2	65..154	CDD:372319	44/88 (50%)
		ANK repeat	90..121	CDD:293786	18/30 (60%)
		ANK repeat	123..154	CDD:293786	15/30 (50%)
		ANK repeat	156..247	CDD:293786	25/94 (27%)
		ANK repeat	249..280	CDD:293786	14/30 (47%)
		Hamartin	<530..849	CDD:367919	28/121 (23%)
		DUF5585	535..>672	CDD:375359	28/116 (24%)
		PRKG1_interact	936..1042	CDD:374206
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810