Protein Alignment MYPT-75D and Ppp1r12b

DIOPT Version :10

• Sequence 1: NP_649049.1
• Gene: MYPT-75D / 40032
• FlyBaseID: FBgn0036801
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_063128373.1
• Gene: Ppp1r12b / 304813
• RGDID: 1309287
• Length: 1038
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 180/725 - (24%)
• Similarity: 317/725 - (43%)
• Gaps: 118/725 - (16%)

  Fly    42 ERLQLARLRRAQQLKLSRQKDKEWAKLQRAKGNTASGGSGTGSLGNGLMNGNGDTTHHFRHANGS 106
            :|.:.||.|||:||       :.|                .|||          |........|:
  Rat    10 KRAESARARRAEQL-------RRW----------------RGSL----------TEQEPAERQGA 41

  Fly   107 G----TLSGRRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEM 167
            |    |..|...:.||:..|.|.|.|..|..||..||..|...:..|.|||||:||||||.|::|
  Rat    42 GRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEVKKLLARGADINTVNVDGLTALHQACIDENLDM 106

  Fly   168 LQLLLEYGANVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLD 232
            ::.|:|..||::.||::.||||||||:||:|.:....|.|||::..||::|.:|.||.::....|
  Rat   107 VKFLVENRANINQQDNEGWTPLHAAASCGYLNIAEYFISHGASVGIVNSEGEVPSDLAEEPAMKD 171

  Fly   233 FIEGEMAQRGVTQELIDETRSSTERIMLRDLMELARTG--GDLEEPDYQCATPLHIAAANGYVRV 295
            .:..::.::||.   ::::|...|:.||:|..:...:|  .|:.:. ...||.||:|||.||..|
  Rat   172 LLLEQVKKQGVD---LEQSRKEEEQQMLQDARQWLNSGKIEDVRQA-RSGATALHVAAAKGYSEV 232

  Fly   296 VEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICEDPEIRE 360
            :..|::....::..|.|.|||:||||.||..|...:||:...|:::|||..:||.|:. |..:.|
  Rat   233 LRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA-DEGLVE 296

  Fly   361 RIEQLKTEQESKRLAEAQRRRVRRSQSNNTRAQSVRRTSLRDKTL----TTKKDAVEETRLRLQA 421
            .:|.|:.:|:..|..:..|.::..|..|:.....:.:.  ::|.|    ..|....||......:
  Rat   297 HLEMLQKKQDVLRSEKETRNKLIESDLNSKFQSGLFKN--KEKMLYEEEIPKSQETEEENKESSS 359

  Fly   422 QEATDSEAPSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADAL----DNATAALSANA 482
            ..:.:.|......:..|      ....:|:|....::......|:..:.:    .|..:|.||..
  Rat   360 SSSEEEEGEDEVSESET------EKEADKKPEVTVNHSNSESKSRIVEQIPTPAQNTFSASSARR 418

  Fly   483 THSY--PSRRPPDGRENDELLRLKAAGAAGEMQRATSAAAVILTEKGTAASAEAVQIQSSKEAAN 545
            ....  .:..|.|...:...|.|:..|:...:...|:.... |.::|::.         .:.:::
  Rat   419 LSGLFNKAEEPKDESPSSWRLGLRKTGSHNMLSEVTNPREA-LRDRGSSI---------YRSSSS 473

  Fly   546 GKINVQVTVLVDTNSTHHHQQH---------QQQQQQQQQHHHQQHVLLLQQHQQLQQ-HQQQQQ 600
            .:|:   |:|.|.:....::.:         ......:::.:.:..|.|::.....:| .:.:.:
  Rat   474 PRIS---TLLDDKDKERENRSYFSTLVPRRLSGTSDIEEKENRESAVNLVRSGSHTRQLWRDEAK 535

  Fly   601 QQQQQQHVALDGYSATLANLKKQRSLSRTANVLNTFELSSQTASNAHPIAAANATTTNGSVLGAG 665
            ..:..|.||...|::|..   |..|..::::..:.:..:::.:|.|.......::|:.||.....
  Rat   536 GNETPQTVAPSTYTSTYL---KSASFGKSSDPTSPYISANRNSSPATSPITIGSSTSRGSQWQPA 597

  Fly   666 GSSSNNNNNLSTSNNNNNGSAPISTQPTLGHMGAGSVLSDFEGSSPAGSSLNKFSGITGDVVTDS 730
            .|.                .||:||..|   .....|.:.::  |.|.|:..:         |||
  Rat   598 SSC----------------PAPVSTNTT---ASVQHVRTPYK--SQADSTAER---------TDS 632

  Fly   731 TSSSRRCCVL 740
            .|||...||:
  Rat   633 GSSSTPLCVI 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_649049.1	ANKYR	123..366	CDD:440430	95/244 (39%)
		ANK repeat	123..149	CDD:293786	9/25 (36%)
		ANK repeat	151..182	CDD:293786	17/30 (57%)
		ANK repeat	184..215	CDD:293786	15/30 (50%)
		ANK repeat	217..310	CDD:293786	25/94 (27%)
		Ank_4	<259..300	CDD:372654	15/42 (36%)
		ANK repeat	312..343	CDD:293786	14/30 (47%)
Ppp1r12b	XP_063128373.1	None