DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYPT-75D and Ppp1r12a

DIOPT Version :10

Sequence 1:NP_649049.1 Gene:MYPT-75D / 40032 FlyBaseID:FBgn0036801 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_001355665.1 Gene:Ppp1r12a / 17931 MGIID:1309528 Length:1029 Species:Mus musculus


Alignment Length:704 Identity:180/704 - (25%)
Similarity:303/704 - (43%) Gaps:141/704 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 ISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEMLQLLLEYGANVD 179
            :.|::..|.|.|.|..|..||..||..|...:.||.|||||:||||||:||:|::.|:|.|||::
Mouse    36 VKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANIN 100

  Fly   180 AQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLDFIEGEMAQRGVT 244
            ..|::.|.||||||:||:|::...||..||::.|||::|:.|.|:.::|...:.::.|:.::||.
Mouse   101 QPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165

  Fly   245 QELIDETRSSTERIMLRDLMEL-----------ARTGGDLEEPDYQCATPLHIAAANGYVRVVEF 298
               |:..|...||:||||..:.           |::||          |.||:|||.||..|::.
Mouse   166 ---IEAARKEEERVMLRDARQWLNSGHISDVRHAKSGG----------TALHVAAAKGYTEVLKL 217

  Fly   299 LLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICED------PE 357
            |::...:|:..|.|.|||:||||.||..|...:|.....|:...||..:|..|:.::      .|
Mouse   218 LIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEE 282

  Fly   358 IRERIEQLKTEQESKR------LAEAQRRRVRRS-----------QSNNTRAQSVRRTSLRDKTL 405
            ::::...|.:|:..|:      .|..:..:.:::           :.|.:|.:|:.... .|:..
Mouse   283 LQKKQTLLHSEKRDKKSPLIESTANMENNQPQKAFKNKETLIIEPEKNASRIESLEHEK-ADEEE 346

  Fly   406 TTKKDAVEETRLRLQAQEATDSEAPSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADA 470
            ..|||   |:....:..|..|||:.:              ...:.:|....||.    |:.|..|
Mouse   347 EGKKD---ESSCSSEEDEEDDSESEA--------------ETDKTKPMASVSNA----HTSSTQA 390

  Fly   471 LDNATAA--LSAN-ATHSYPSRR---------PPDGRENDE-----LLRLKAAGAAGEMQRATSA 518
            ...|..|  ||:| .|.:.|.::         |.:....||     .|.|:..|:.|.:.. .||
Mouse   391 APAAVTAPTLSSNQGTPTSPVKKFPISTTKISPKEEERKDESPASWRLGLRKTGSYGALAE-ISA 454

  Fly   519 AAVILTEKGTAA---SAEAVQIQSS-----KEAAN-GKINVQVTVLVDTNSTHHHQQHQQQQQQQ 574
            :.....||.||.   ||.:.::.||     ||..| |.....||..:...........:::.::.
Mouse   455 SKEAQKEKDTAGVMRSASSPRLSSSLDNKEKEKDNKGTRLAYVTPTIPRRLASTSDIEEKENRES 519

  Fly   575 QQHHHQQHVLLLQQHQQLQQHQQQQQQQQQQQHVAL-----DGYSATLANLKKQRSLSRTANVLN 634
            ............:....|:::....:.....:..:.     |..|.::.:.....:::..|.:..
Mouse   520 SSLRTSSSYTRRKWEDDLKKNSSINEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTVTSAAGLQR 584

  Fly   635 TFELSSQTASNAHPIAAANATTTNGSVLGAGGSSSNNNNNL--STSNNNNNGSAP----ISTQPT 693
            :...|:.||:...|          ||  .:.|:.|:.:|.|  ..|......|||    |...||
Mouse   585 SLPSSTSTAAKTPP----------GS--SSAGTQSSTSNRLWAEDSTEKEKDSAPTAVTIPVAPT 637

  Fly   694 LGHMGAGSVLSDFEGSSPAGSSL-NKFSGITGDV----------VTDSTSSSRR 736
            :           ...::|:.::| ...:|...:|          |.|..|.|:|
Mouse   638 V-----------VNAAAPSTTTLTTTTAGTVSEVRERRRSYLTPVRDEESESQR 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYPT-75DNP_649049.1 ANKYR 123..366 CDD:440430 96/259 (37%)
ANK repeat 123..149 CDD:293786 9/25 (36%)
ANK repeat 151..182 CDD:293786 19/30 (63%)
ANK repeat 184..215 CDD:293786 15/30 (50%)
ANK repeat 217..310 CDD:293786 29/103 (28%)
Ank_4 <259..300 CDD:372654 16/51 (31%)
ANK repeat 312..343 CDD:293786 13/30 (43%)
Ppp1r12aNP_001355665.1 KVKF motif 35..38 0/1 (0%)
ANKYR 39..331 CDD:440430 101/304 (33%)
ANK 1 39..68 10/28 (36%)
ANK repeat 72..103 CDD:293786 19/30 (63%)
ANK 2 72..101 19/28 (68%)
ANK repeat 105..136 CDD:293786 15/30 (50%)
ANK 3 105..134 14/28 (50%)
ANK repeat 138..229 CDD:293786 29/103 (28%)
ANK 4 138..164 5/25 (20%)
ANK 5 198..227 13/38 (34%)
ANK repeat 231..262 CDD:293786 13/30 (43%)
ANK 6 231..260 13/28 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 290..786 82/437 (19%)
IPD_MYPT1 658..712 CDD:412019 6/23 (26%)
Interaction with ROCK2. /evidence=ECO:0000250 680..863 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 808..927
PRKG1_interact 930..1029 CDD:464927
Blue background indicates that the domain is not in the aligned region.

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