Protein Alignment MYPT-75D and mel-11

DIOPT Version :10

• Sequence 1: NP_649049.1
• Gene: MYPT-75D / 40032
• FlyBaseID: FBgn0036801
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001021928.1
• Gene: mel-11 / 174484
• WormBaseID: WBGene00003196
• Length: 1124
• Species: Caenorhabditis elegans
• Alignment Length: 773
• Identity: 184/773 - (23%)
• Similarity: 291/773 - (37%)
• Gaps: 189/773 - (24%)

  Fly   112 RRHISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEMLQLLLEYGA 176
            |..:.|::|.:.|.|....|..||..||..|...:....|||||:||:.||:..||::.|.|.||
 Worm    48 RPKVQFQDSDIFLSACMSGDEEEVEELLNKGANINTCTVDGLTALHQSVIDSKPEMVRFLCEKGA 112

  Fly   177 NVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLDFIEGEMAQR 241
            :|:|||::.||||||||.||::.:||.|.:|||:|..||:|..:..||..||:..|:::.:..::
 Worm   113 DVNAQDNEGWTPLHAAACCGNVAIVRYLCQHGADLSIVNSDKELALDLAVDEQCRDYLDDDYKRQ 177

  Fly   242 GVTQELIDETRSSTERIMLRDL-MELA----------RTGGDLEEPDYQCATPLHIAAANGYVRV 295
            .:.   :|..|....:.||:|: |.::          ||||          |.:|:||..||.::
 Worm   178 MID---LDACRDQELQTMLKDVNMWMSQGEYRDIPHHRTGG----------TAMHVAAGRGYTQL 229

  Fly   296 VEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLN-------------------- 340
            :|.|::...||.|.|.:.|||:||||.|...:..::|.:.||:|:
 Worm   230 LELLIKAGGNVRAQDVEGWTPLHAAAHWAERDACKILLENGAELSDLTFTGADVLGVADKECIDY 294

  Fly   341 ---------VRNKDDETPSDICEDPE--IRERIEQLKTEQESKRLAEAQRRRVRRSQ-------- 386
                     |:|| .::|....:.|.  ::|:..::.:.:|....:|.:|....:.|
 Worm   295 LVELADTVKVQNK-RKSPGSGSQPPTSILQEKNHRMPSHEEHVLTSERKRDLQHKDQHSENEFLH 358

  Fly   387 SNNTRAQSVRRTSLRDKTLTT--------------------KKDAV--EETRLRLQAQEATDSEA 429
            |:.:.|.....||....|.||                    |:.||  ||.....:.:||.:.|.
 Worm   359 SHPSTASVGSTTSSNTNTTTTTIVIGENDISAAQKDSRESSKESAVDDEEYVAEDEMEEAEEDEE 423

  Fly   430 PSSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADALDNATAALSANATHSYP--SRRPP 492
            ....           ....|::......||:.:...:|     ..|::.|.:.|.|..  :.|..
 Worm   424 EEDV-----------EEEEEEKSEAELKNGKEISPLRS-----ETTSSRSISITRSLDGYTDRSS 472

  Fly   493 DGREN----DELLRLKAAGAAGEMQRAT--------SAAAVILTEKGTAASAEAVQIQSSKEAAN 545
            .|||.    .|.....:.|......|.|        |||..:.||  |..|:    :::|....:
 Worm   473 SGRETSAEMSEAASSASTGTTSSSSRFTSSTPSSQRSAAGSVHTE--TPRSS----MENSSSVGS 531

  Fly   546 GKINVQVTVLVDTNSTHHHQQHQQQQQ------QQQQHHHQQHVLLLQQHQQLQQHQQQQQQQQQ 604
            |..||..|:.:...|......||....      ..........|.........:..........|
 Worm   532 GDQNVSATIPIVPLSAPPKAVHQSPSSWINRGVPLSSRSSTSSVTRSSSTPVSEIISPPSSIHSQ 596

  Fly   605 QQHVALDGYSATLANLKKQRSLSRTANVLNTFELS-SQTASNAHPIAAANATTTNGS-------- 660
            ....::...:.|.|.:....|...:..|.|....: |.||.|. |..|.:.||.|.:
 Worm   597 LSFPSVSNTTTTTATVAPTSSTVPSTPVSNVMAATISSTAKNT-PSPAGSVTTINATFSKPSSRH 660

  Fly   661 ----VLGAGGSSSN--------NNNNLST------------------------------------ 677
                |..:....:|        |.||.||
 Worm   661 PSEEVYRSPSQPTNVPWASLWHNVNNASTGQIRSHIEQLRNASFSSLSSYPRVSAFRSPIKTTAS 725

  Fly   678 SNNNNNGSAPISTQPTLGHMGAGSVLSDFEGSSPAGSSLNKFSGITGDVVTDSTSSSR 735
            |.:.|:.|:|:..||   |.....:.....|..|...:.||.|......||:|.:..|
 Worm   726 STSVNSASSPLLLQP---HPHPPVIAEYPRGFVPQQINPNKMSRWQSKTVTESEAERR 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_649049.1	ANKYR	123..366	CDD:440430	92/284 (32%)
		ANK repeat	123..149	CDD:293786	8/25 (32%)
		ANK repeat	151..182	CDD:293786	17/30 (57%)
		ANK repeat	184..215	CDD:293786	17/30 (57%)
		ANK repeat	217..310	CDD:293786	27/103 (26%)
		Ank_4	<259..300	CDD:372654	15/51 (29%)
		ANK repeat	312..343	CDD:293786	13/59 (22%)
mel-11	NP_001021928.1	ANKYR	<54..307	CDD:440430	88/265 (33%)
		ANK repeat	87..118	CDD:293786	17/30 (57%)
		ANK repeat	120..151	CDD:293786	17/30 (57%)
		ANK repeat	153..244	CDD:293786	27/103 (26%)
		ANK repeat	246..271	CDD:293786	9/24 (38%)
		ANK repeat	279..306	CDD:293786	1/26 (4%)
		IPD_PPP1R12	760..806	CDD:412018	7/21 (33%)
		PRKG1_interact	1011..1124	CDD:464927