DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and PPP1R27

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001007534.1	Gene:	PPP1R27 / 116729	HGNCID:	16813	Length:	154	Species:	Homo sapiens

Alignment Length:	121	Identity:	43/121 - (35%)
Similarity:	72/121 - (59%)	Gaps:	2/121 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RHISFENSVVLLEAASRNDMPEVAALLQ-HGITPDAANEDGLTAMHQACIDNNVEMLQLLLEYGA 176
            |.:.|.|.|:.|:...:.|:.:|...:: ..::....:..||.|:|:|.:..|:|.::||::|||
Human    24 RSVRFPNDVLFLDHIRQGDLEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGA 88

  Fly   177 NVDAQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCD-DEKTL 231
            ::..:|...|||||.|.:.|:.::.|.||..||:..|.|.||::|.||.| |.|.|
Human    89 DIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKEL 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	29/92 (32%)
		ANK repeat	123..149	CDD:293786	3/26 (12%)
		ANK	146..332	CDD:238125	36/87 (41%)
		ANK repeat	151..182	CDD:293786	12/30 (40%)
		ANK repeat	184..215	CDD:293786	13/30 (43%)
		ANK repeat	217..310	CDD:293786	9/16 (56%)
		Ank_4	282..332	CDD:290365
		ANK repeat	312..343	CDD:293786
		Ank_4	314..>353	CDD:290365
PPP1R27	NP_001007534.1	ANK	38..147	CDD:238125	38/107 (36%)
		ANK repeat	63..94	CDD:293786	12/30 (40%)
		ANK 1	63..92		12/28 (43%)
		ANK repeat	96..127	CDD:293786	13/30 (43%)
		ANK 2	96..125		12/28 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810