DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYPT-75D and ppp1r12a

DIOPT Version :9

Sequence 1:	NP_001262018.1	Gene:	MYPT-75D / 40032	FlyBaseID:	FBgn0036801	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_031754809.1	Gene:	ppp1r12a / 100493563	XenbaseID:	XB-GENE-5896537	Length:	1064	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	175/726 - (24%)
Similarity:	308/726 - (42%)	Gaps:	146/726 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ISFENSVVLLEAASRNDMPEVAALLQHGITPDAANEDGLTAMHQACIDNNVEMLQLLLEYGANVD 179
            :.|::..|.|.|.|..|..||..||..|...:.||.|||||:||||||:|::|::.|:|:||.::
Frog    36 VKFDDGAVFLAACSSGDTDEVLKLLDRGADINYANVDGLTALHQACIDDNIDMVKFLVEHGAGIN 100

  Fly   180 AQDSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLDFIEGEMAQRGVT 244
            ..|::.|.|||||::||:|::...||..||::..||::|:.|.|:.::|...|.::.|:.::|:.
Frog   101 QPDNEGWIPLHAASSCGYLDIAEYLISKGASVGVVNSEGDTPLDIAEEEAMEDLLQNEVNRQGID 165

  Fly   245 QELIDETRSSTERIMLRDLMELARTG--GDLEEPDYQCATPLHIAAANGYVRVVEFLLEQHVNVD 307
               ::..|...|||||||..:...:|  .|:.. .....|.||:|||.||..|::.||:...:|:
Frog   166 ---VEAARKEEERIMLRDARQWLNSGQINDIRH-SKSGGTALHVAAAKGYTEVLKLLLQAGYDVN 226

  Fly   308 AMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDDETPSDICEDPEIRERIEQLKTEQESK 372
            ..|.|.|||:||||.||..|..::|.:...::...||..:|..|:. |.:|...:|:|:.:| :.
Frog   227 VKDFDGWTPLHAAAHWGKEEACKILVENFCNVEAVNKVGQTALDVA-DEDILSYLEELQKKQ-NL 289

  Fly   373 RLAEAQRRRVRRSQSNNTRAQSVRRTSLRDKTLTTKK-------DAVEETRLRLQAQEATDSEAP 430
            .|:|.|.::....:|:.|......:|....:||..::       |::||.:...:.:...|..:.
Frog   290 LLSEKQEKKSPLIESSTTENNQSLKTLKNKETLIIEQEKTVSAIDSLEEEKADEEDEGKKDESSC 354

  Fly   431 SSAGDPLTNGYGYGNNNGEKRPSTGSSNGQPLPHSKSADALDNATAALSANATHS---------- 485
            ||..:.        ..:.|....|..:......:|.:::::..|:....::..||
Frog   355 SSEEEE--------EEDSESEAETDKTKSLSSVNSINSNSIPQASVTAVSSTVHSGQVTPTSPVK 411

  Fly   486 -------------------------------YPSR-------RPP---DGRENDE--------LL 501
                                           .||:       .||   ..:|.|.        .|
Frog   412 KYEFIAPFMPVVETMHPTSWRQGLRKTGIVLVPSKGDKSLFPTPPGKTSPKEEDRKDESPASWRL 476

  Fly   502 RLKAAGAAGEMQRATSAAAVILTEK---GTAASAEAVQIQSS-------KEAANGKI-NVQVTV- 554
            .|:..|:.|.:...| |:.....|:   |...||.:.::.|:       |:....:: .|..|:
Frog   477 GLRKTGSYGALSEIT-ASKEAQKERDFTGVMRSASSPRLSSTLDNKEKEKDGRGARLAYVAPTIP 540

  Fly   555 --LVDTNSTHHHQQH--------------QQQQQQQQQHHHQQHVLLLQQHQQLQQHQQQQQQQQ 603
              |..|:.....:..              :::..:..:.:...:.||...:|:.....::|....
Frog   541 RRLASTSDIEEKENRDSSLGFLRGSSSYTRRKWDEDFKKNTSVNELLNTSYQRSSSFGRRQDDLV 605

  Fly   604 QQQHVALDGYSATLANLKKQRSLSRTANVLNTFELSSQTASNAHPIAAANATTTNGSVLGAGGSS 668
            ..   ...|.:||:.:....||.|.|.|    ...|:.::|:..|.:.:|.       ..|..||
Frog   606 SS---IPPGSTATVTSSGLARSYSSTIN----SGRSTVSSSSGLPSSTSNR-------FWADDSS 656

  Fly   669 SNNNNNLSTSNNNNNGSAPI--------STQPTLGHMGAGSVLSDFEGSSPAGSSLNKFSGITGD 725
            ..:.:.:||:     .:.|:        ||..|:.....|:|.|..|......|.|..
Frog   657 EKDKDTVSTA-----VTIPVAPTILNTTSTSTTMTTTSTGTVPSSAEVRERRRSYLTP------- 709

  Fly   726 VVTDSTSSSRR 736
             |.|..|.|:|
Frog   710 -VRDEESESQR 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYPT-75D	NP_001262018.1	Ank_2	123..215	CDD:289560	42/91 (46%)
		ANK repeat	123..149	CDD:293786	9/25 (36%)
		ANK	146..332	CDD:238125	76/187 (41%)
		ANK repeat	151..182	CDD:293786	17/30 (57%)
		ANK repeat	184..215	CDD:293786	13/30 (43%)
		ANK repeat	217..310	CDD:293786	29/94 (31%)
		Ank_4	282..332	CDD:290365	24/49 (49%)
		ANK repeat	312..343	CDD:293786	12/30 (40%)
		Ank_4	314..>353	CDD:290365	15/38 (39%)
ppp1r12a	XP_031754809.1	PHA03095	43..>272	CDD:222980	91/232 (39%)
		ANK repeat	72..103	CDD:293786	17/30 (57%)
		ANK repeat	105..136	CDD:293786	13/30 (43%)
		ANK repeat	198..229	CDD:293786	12/30 (40%)
		ANK repeat	231..262	CDD:293786	12/30 (40%)
		IPD_PPP1R12	695..751	CDD:424067	9/33 (27%)
		PRKG1_interact	965..1063	CDD:406350
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910