DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bora and arhgap35

DIOPT Version :9

Sequence 1:	NP_649048.1	Gene:	bora / 40031	FlyBaseID:	FBgn0259791	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_004917008.1	Gene:	arhgap35 / 100498460	XenbaseID:	XB-GENE-999477	Length:	1472	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	98/512 - (19%)
Similarity:	166/512 - (32%)	Gaps:	146/512 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KENGKYSPQMSGNVCTPPPKRLHKVRNPFEGAMADRLHLPLIASPSLFRSRTPQLSSTQFEWNID 114
            :|..:.:..:.|.....|..::....:.|.....|.|...:|...|.....|.:..||     .:
Frog   899 QEGEEIAQDIEGKFLILPQGQIQPKLDVFYPYFKDVLEKKVIIEASHMYDNTAEACST-----TE 958

  Fly   115 EVSQLKPADVEP----HETQFHDSPDPEQESKAQLAISAFFKESLIVPSPVDCPLRKQRIILNCS 175
            ||.. .|....|    |.....:.|:|..:       ...|:....:.:|:......:..::|..
Frog   959 EVFS-SPRAGSPLCNSHLPDSEEDPEPSPQ-------HILFQNEPNIAAPIKFTRELEETVMNTL 1015

  Fly   176 EDNTPISNKSRRMRDCEVQTELTLPPILPKALEDALRPY--FQPHLA----GRLSGRSK---SSG 231
            |  :.::||             ..||:.||    ...||  .:|.|:    |...|..|   |..
Frog  1016 E--SKLNNK-------------VPPPLKPK----PPIPYEITKPELSYLDTGARDGHRKSLTSIN 1061

  Fly   232 GPDIFNSSMRRKLFDLHNVIVLGEQDTAEPSRSMVGSSPQGKQTMFAGRLSDSASGESSFGCLSP 296
            .|.:       :.||        ..|.|||..|:|  .|:.::........||..|:     :..
Frog  1062 WPPL-------EAFD--------PSDYAEPMDSVV--KPRNQEENIYSVPHDSTQGK-----IIT 1104

  Fly   297 IRNLCGLPPGTP-DNGTCSGKRKLLMHELELPSPIAPSEHLSRRLVHSKVEISVTEQHDTLSERT 360
            |||     ...| .||:.:|               :.|:..:..|..::....||:   .:..||
Frog  1105 IRN-----TNKPQSNGSGNG---------------SDSDMDTNSLERARKASIVTK---PVLYRT 1146

  Fly   361 AL----KFTPDRSSSPMGGGLEHSDCSINQRVRRLRVNSTRQVVIETGDQPLFEETEGEEEEAES 421
            ..    ||:..|||..:|...|...      :||...        |||.|....::.....||:.
Frog  1147 KCAKLGKFSSYRSSLSVGSDDEPGP------IRRKEE--------ETGTQGTKGDSTTNSYEADG 1197

  Fly   422 EDDEEADAMQLSTVSFNCSSSNSDTPRGHKRHRSAQRKNLSQSFSANLEEEADQTQGGAGSIQPA 486
            ||..:.:.::             ...|..|:.:...|.:|:::     ..|::.......|:..:
Frog  1198 EDPRKRNILR-------------SLRRTTKKVKPKPRPSLTKA-----TWESNYFGFPLSSVVTS 1244

  Fly   487 EPP---------------SVAMPQQGARIPLYRADSGFNETSSTTFAFSQDLPLDVS 528
            |.|               ...|..:|    :||.....:|..|....|.||..||::
Frog  1245 ERPIPVFIEKCVEYIEATGEGMTTEG----IYRVSGNKSEMESLQRQFDQDHNLDLA 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bora	NP_649048.1	BORA_N	60..258	CDD:317655	38/210 (18%)
arhgap35	XP_004917008.1	Ras_like_GTPase	29..245	CDD:206648
		Ras	<158..247	CDD:395024
		RhoGAP-FF1	261..340	CDD:406821
		FF	429..>470	CDD:128718
		FF	485..538	CDD:128718
		pseudoGTPaseD_p190RhoGAP	589..760	CDD:425412
		PHA03151	1036..1225	CDD:177546	52/260 (20%)
		RhoGAP_p190	1234..1420	CDD:239838	14/68 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165178214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930