DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP3

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_006528.2	Gene:	USP3 / 9960	HGNCID:	12626	Length:	520	Species:	Homo sapiens

Alignment Length:	487	Identity:	145/487 - (29%)
Similarity:	232/487 - (47%)	Gaps:	64/487 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKK-----HNVALELSHGTLYCYACRDFIYD 103
            |:...||.| :..:|..|   :......:|:|.:|:|     |.|.::.|..:.|||.|.||:
Human    44 CSSVHCGRY-VNGHAKKH---YEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFV-- 102

  Fly   104 ARSREYALINRKLE-AKDLQKSIGWVPWVPTTKETNLLLANA--RRRLVRPN---QTIGLRGLLN 162
            ....:..|:.:..| .::|:.|    .:.....:...||.|:  ..:|::.|   ..|...||.|
Human   103 VNDTKLGLVQKVREHLQNLENS----AFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRN 163

  Fly   163 LGATCFMNCIVQALVHTPLLSDYF-------MSDRHDCGSKSSHK--------CLVCEVSRLFQE 212
            ||.|||||.|:|:|.:......||       :.:....|.::.|.        .||.|..:....
Human   164 LGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCA 228

  Fly   213 FYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSG-S 276
            .:.||::..|...|.:::|....:..||:|||||||....||.||.         |.:...:| |
Human   229 LWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL---------ELQGGFNGVS 284

  Fly   277 GSGTNSSNS----SSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL----- 332
            .|.....||    |:..|....:.::..||.|:||::|.|..|...|..:|||.|:|||:
Human   285 RSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFR 349

  Fly   333 ---GETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLK 394
               .:...:|.|.  :|.|||..:|..|.|.......|..||..|:|||:|.::.||.|:..|||
Human   350 SKRSKNQENGPVC--SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLK 412

  Fly   395 RFEHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGD-FRFSLYAVVNHVGT-IDTGHYTAYVR 456
            ||..:|.:..|:.::::||:. .||..::.|.:|:..: ..:.|.|||.|.|: :.:||||||..
Human   413 RFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYAT 477

  Fly   457 HQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |: ..|...:|..:|:...:.|:.::.|:|||
Human   478 HE-GRWFHFNDSTVTLTDEETVVKAKAYILFY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/61 (30%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	116/362 (32%)
USP3	NP_006528.2	zf-UBP	29..105	CDD:307999	19/66 (29%)
USP3	NP_006528.2	UCH	159..508	CDD:306860	114/360 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D929408at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850