DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP34

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_055524.3	Gene:	USP34 / 9736	HGNCID:	20066	Length:	3546	Species:	Homo sapiens

Alignment Length:	621	Identity:	114/621 - (18%)
Similarity:	206/621 - (33%)	Gaps:	229/621 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GCRHY---------QSYVKEHSYDTFRVIDA---YFAACVNRDARERKAI--------------- 42
            ||:.|         ..::|:.|..|...:||   :.|.|:    |.|:.:
Human  1730 GCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCI----RSREILDHQDGNVEDDGLTGL 1790

  Fly    43 ---------HCNCFECGSYGIQLYACLHCIYF-----------GCRGAHITSH-LRSKKHNVALE 86
                     |...|:....|.:....:..:.|           .|:     || .|:..:::.:|
Human  1791 LRLATSVVKHKPPFKFSREGQEFLRDIFNLLFLLPSLKDRQQPKCK-----SHSSRAAAYDLLVE 1850

  Fly    87 LSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQK--SIGWVPWVPTTKETNLLLANARRRLV 149
            :..|::              ..|.||:..:.|:.:|.  ...|..|
Human  1851 MVKGSV--------------ENYRLIHNWVMAQHMQSHAPYKWDYW------------------- 1882

  Fly   150 RPNQTIGLR----GLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLF 210
             |::.:...    ||.||||||::...:|.|...|.......:.::....|  ||..:.|:.::|
Human  1883 -PHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDMK--HKTTLLELQKMF 1944

  Fly   211 Q----------------EFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRH 259
            .                :.|:..:.||:..                ||:|..|||   .|::
Human  1945 TYLMESECKAYNPRPFCKTYTMDKQPLNTG----------------EQKDMTEFF---TDLI--- 1987

  Fly   260 CVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDP 324
               .|.|..|.                      :....:..:|.|::.::||...|..||.|.:.
Human  1988 ---TKIEEMSP----------------------ELKNTVKSLFGGVITNNVVSLDCEHVSQTAEE 2027

  Fly   325 FWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVV 389
            |:.:...:.:.        |.:.:.|:..|..:.|.......||.|.....:.|:...:.||.::
Human  2028 FYTVRCQVADM--------KNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRIL 2084

  Fly   390 SFHLKR--FEHSALIDRKISSFIQFPVEFDMTPF-------MSEKKNAYGD----------FRFS 435
            ||:..|  |....::..|:::...||:..||||:       .||:|..:.:          :.:.
Human  2085 SFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSERKEGFKEVSDHSKDSESYEYD 2149

  Fly   436 LYAVVNHVGTIDTGHYTAYVR-------HQKDTWV-----------------KCDDHVITMASLK 476
            |..|..|.||.|.|||.:::|       ::.:.|.                 :|....:|..:..
Human  2150 LIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYD 2214

  Fly   477 QVLDS----------EGYLLFY------HKNVLEYE 496
            .|.|.          ..|:|||      .:|..||:
Human  2215 SVTDKFMDFSFEKTHSAYMLFYKRMEPEEENGREYK 2250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	9/68 (13%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	81/409 (20%)
USP34	NP_055524.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..679
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1459..1478
		peptidase_C19C	1892..2241	CDD:239124	81/405 (20%)
		UCH	1894..2236	CDD:278850	79/398 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3331..3443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910